Renal cell carcinoma classification

Renal cell carcinoma Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Renal cell carcinoma from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural history, Complications and Prognosis
Diagnosis
Staging
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Renal cell carcinoma classification On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Renal cell carcinoma classification All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Renal cell carcinoma classification
CDC on Renal cell carcinoma classification
Renal cell carcinoma classification in the news
Blogs on Renal cell carcinoma classification
Directions to Hospitals Treating Renal cell carcinoma
Risk calculators and risk factors for Renal cell carcinoma classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Classification

The following tables classify renal cell carcinoma according to histologic appearance and differentiates sporadic from hereditary forms of renal cell carcinoma.

Sporadic Forms of Renal Cell Carcinoma

Histologic Appearance	Incidence	Gene	Frequency
Conventional	75	VHL	60 %
Papillary	12	MET TFE3	13 % < 1 %
Chromophobe	4
Oncocytoma	4
Collecting Duct	< 1
Unclassified	3 - 5

^{Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.N Engl J Med. 2005; 353:2477-90}

Hereditary Forms of Renal Cell Carcinoma

Syndrome	Associated Gene	Common Histological Appearance
VHL Disease	VHL	Conventional
FCRC	Chromosome 3p translocation	Conventional
Hereditary paraganglioma	SDHB	Conventional
HPRC	MET	Papillary
HLRCC	FH	Papillary
Birt-Hogg-Dube Syndrome	BHD	Chromophobe / Oncocytoma

^{Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.N Engl J Med. 2005; 353:2477-90}

• Clear cell carcinoma (VHL and others on chromosome 3)
• Papillary carcinoma (MET, PRCC)
• Chromophobe renal carcinoma
• Collecting duct carcinoma

References

Template:WH Template:WS