Loracarbef

Loracarbef

Clinical data
Trade names	Lorabid
AHFS/Drugs.com	Monograph
MedlinePlus	a601206
ATC code	J01DC08 (WHO)
Pharmacokinetic data
Protein binding	25%
Identifiers
IUPAC name (6R,7S)-7-[[(2S)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS Number	76470-66-1 Y
PubChem CID	5284584
DrugBank	DB00447 Y
ChemSpider	4447634 Y
UNII	W72I5ZT78Z
KEGG	D08143 Y
ChEMBL	ChEMBL1013 N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C16H16ClN3O4
Molar mass	349.769 g/mol
3D model (JSmol)	Interactive image
SMILES Cl\C3=C(/C(=O)O)N2C(=O)[C@@H](NC(=O)[C@@H](c1ccccc1)N)[C@H]2CC3.O
InChI InChI=1S/C16H16ClN3O4.H2O/c17-9-6-7-10-12(15(22)20(10)13(9)16(23)24)19-14(21)11(18)8-4-2-1-3-5-8;/h1-5,10-12H,6-7,18H2,(H,19,21)(H,23,24);1H2/t10-,11-,12+;/m1./s1 Y Key:GPYKKBAAPVOCIW-HSASPSRMSA-N Y=  Y=  Y
NY (what is this?)  (verify)

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Loracarbef is an antibiotic. Its use was discontinued in 2006. It is a carbacephem, but it is sometimes grouped together with the second-generation cephalosporin antibiotics. It was marketed under the trade name Lorabid.

Loracarbef is a synthetic "carba" analogue of cefaclor, and is more stable chemically. Diarrhea is the most common adverse effect with Loracarbef. Side effects are more frequently seen with children under the age of twelve. It received FDA approval in 1991.

Category

Carbacephem

US Brand Names

LORABID^®

External links

• RxList.com - Loracarbef