Thiabendazole

Thiabendazole

Clinical data
ATC code	D01AC06 (WHO) P02CA02 (WHO)
Identifiers
IUPAC name 2-(1,3-thiazol-4-yl)-1H-benzoimidazole
CAS Number	148-79-8
PubChem CID	5430
DrugBank	APRD01252
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C10H7N3S
Molar mass	201.249 g/mol
3D model (JSmol)	Interactive image
SMILES [nH]1c2ccccc2nc1c3cscn3

Thiabendazole (or tiabendazole) is a fungicide and parasiticide.

Thiabendazole is abbreviated to "TBZ". It is produced by Merck under the brand name Mintezol®.

Uses

It is used primarily to control mold, blight, and other fungally caused diseases in fruits and vegetables. It is able to control roundworms, hookworms, and other helminth species which attack wild animals, livestock and humans.

Thiabendazole is applied to some bananas, including Chiquita brand bananas 'to ensure freshness'.

Thiabendazole is also a chelating agent, which means that it is used medicinally to bind metals in cases of metal poisoning, such as lead poisoning, mercury poisoning or antimony poisoning.

Thiabendazole is also used as a food additive, a preservative with E number E233.

Thiabendazole is also used to treat ear infections in dogs and cats. It is sold by Merial under the brand name Tresaderm.

The substance appears to have a slight toxicity in higher doses, with effects such as liver and intestine distorder at high exposure in test animals (just below LD50 level). Some reproductive distorders and decreasing weanling weight have been observed, also at high exposure. Effects on humans from use as drug includes nausea, vomiting, loss of appetite, diarrhea, dizziness, drowsiness, or headache; very rarely also ringing in the ears, vision changes, stomach pain, yellowing eyes and skin, dark urine, fever, fatigue, increased thirst and change in the amount of urine. No mutagenic or carcinogenic effects have been shown.