Mupirocin
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]
Overview
Mupirocin (Bactroban or Centany) is an antibiotic of the monoxycarbolic acid class.[1] It was originally isolated from Pseudomonas fluorescens NCIMB 10586,[2] developed by Beecham.
Mupirocin is bacteriostatic at low concentrations and bactericidal at high concentrations.[3] It is used topically and is effective against Gram-positive bacteria, including MRSA.[4] Mupirocin is a mixture of several pseudomonic acids, with pseudomonic acid A (PA-A) constituting greater than 90% of the mixture. Also present in mupirocin are pseudomonic acid B with an additional hydroxyl group at C8,[5] pseudomonic acid C with a double bond between C10 and C11, instead of the epoxide of PA-A,[6] and pseudomonic acid D with a double bond at C4` and C5` in the 9-hydroxy-nonanoic acid portion of mupirocin. The inhibition of RNA synthesis was shown to be a protective mechanism in response to a lack of one amino acid, isoleucine.[7] In vivo studies in Escherichia coli demonstrated that pseudomonic acid inhibits isoleucine t-RNA synthetase (IleRS).[4] This mechanism of action is shared with furanomycin, an analog of isoleucine.[8]
References
- ↑ Mupirocin by antimicrobe.org Editorial Board. Retrieved June 2012
- ↑ Fuller AT, Mellows G, Woolford M, Banks GT, Barrow KD, Chain EB (1971). "Pseudomonic acid: an antibiotic produced by Pseudomonas fluorescens". Nature. 234 (5329): 416–7. doi:10.1038/234416a0. PMID 5003547. Unknown parameter
|month=ignored (help) - ↑ Moodabe, Kate. "Topical antibiotics - more harm than good?". Focus. p. 1. Archived from the original on 2007-07-16. Retrieved 2007-04-20. Unknown parameter
|coauthors=ignored (help) - ↑ 4.0 4.1 Hughes J, Mellows G (1978). "Inhibition of isoleucyl-transfer ribonucleic acid synthetase in Echerichia coli by pseudomonic acid". Biochem. J. 176 (1): 305–18. PMC 1186229. PMID 365175. Unknown parameter
|month=ignored (help) - ↑ Chain EB, Mellows G (1977). "Pseudomonic acid. Part 3. Structure of pseudomonic acid B". J. Chem. Soc. Perkin Trans. I (3): 318–24. doi:10.1039/p19770000318. PMID 402373.
- ↑ Clayton, J; O'Hanlon, Peter J.; Rogers, Norman H. (1980). "ScienceDirect - Tetrahedron Letters: The structure and configuration of pseudomonic acid C". Tetrahedron Letters. 21 (9): 881. doi:10.1016/S0040-4039(00)71533-4.
- ↑ Haseltine WA, Block R (1973). "Synthesis of Guanosine Tetra- and Pentaphosphate Requires the Presence of a Codon-Specific, Uncharged Transfer Ribonucleic Acid in the Acceptor Site of Ribosomes". Proc. Natl. Acad. Sci. U.S.A. 70 (5): 1564–8. doi:10.1073/pnas.70.5.1564. PMC 433543. PMID 4576025. Unknown parameter
|month=ignored (help) - ↑ Tanaka K, Tamaki M, Watanabe S (1969). "Effect of furanomycin on the synthesis of isoleucyl-tRNA". Biochim. Biophys. Acta. 195 (1): 244–5. PMID 4982424. Unknown parameter
|month=ignored (help)