Sandbox encephalitis

Viral Encephalitis Adapted from The management of encephalitis: clinical practice guidelines by the Infectious Diseases Society of America

Viral Encephalitis   ▸  Herpes simplex virus   ▸  Varicella zoster virus   ▸  Cytomegalovirus   ▸  Epstein-Barr virus   ▸  Human herpesvirus 6   ▸  B Virus   ▸  Influenza virus   ▸  Measles virus   ▸  Nipah virus   ▸  West Nile virus   ▸  Japanese encephalitis virus   ▸  St. Louis encephalitis virus

Herpes simplex virus patients with normal renal function ▸ Acyclovir 10 mg/kg IV q8h(for 14-21 days) neonates ▸ Acyclovir 20 mg/kg IV q8h(for 21 days) Varicella zoster virus Preferred Regimen ▸ acyclovir 10–15 mg/kg IV q8h (for 10–14 days) PLUS ▸ Cefotaxime 50 mg/kg IV q6—8h Alternative Regimen ▸ Ganciclovir Cytomegalovirus Preferred Regimen ▸ Ganciclovir 5 mg/kg IV q12 h PLUS ▸ Foscarnet 60 mg/kg IV q8h or 90 mg/kg IV q12h Epstein-Barr virus Preferred Regimen ▸ Valacyclovir 5 mg/kg IV q12 h Alternative Regimen ▸ Ganciclovir AND ▸ Acyclovir Human herpesvirus 6 Immunocompromised Patients ▸ Ganciclovir 5 mg/kg IV q12 h OR ▸ Foscarnet 60 mg/kg IV q8h or 90 mg/kg IV q12h Immunocompetent Patients ▸ No good data on effectiveness yet B virus Preferred Regimen ▸ Valacyclovir 5 mg/kg IV q12 h Alternative Regimen ▸ Ganciclovir AND ▸ Acyclovir Influenza virus Preferred Regimen ▸ Oseltamivir Measles virus Preferred Regimen Nipah virus Preferred Regimen West Nile virus Preferred Regimen Japanese encephalitis virus Preferred Regimen ▸ IFN-a is not recommended St. Louis encephalitis virus Preferred Regimen ▸ IFN-2a