Isosorbide mononitrate drug interactions
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]
Isosorbide mononitrate extended-release tablets are indicated for the prevention of angina pectoris due to coronary artery disease. The onset of action of oral ISMN is not sufficiently rapid for this product to be useful in aborting an acute angina episode.
The concomitant administration of agents with hypotensive effects and psychotherapeutic agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics), narcotic analgesics, alcohol, or muscle relaxants may additively increase hypotensive and/or central nervous system depressant effects
Major Interactions
Moderate Interactions
- 40 Winks
- Abilify
- Abilify Discmelt
- Accupril
- Aceon
- Actiq
- Activase
- Adapin
- Adgan
- Aler-Dryl
- Aler-Tab
- Alfenta
- alfentanil
- All Day Allergy
- Allergia-C
- Allermax
- alprazolam
- alprazolam extended release
- Altace
- Altaryl
- alteplase
- Ambien
- Ambien CR
- amitriptyline
- amoxapine
- Anafranil
- Anergan 50
- Antiflex
- Antinaus 50
- APO-Go
- APO-Go Pen
- Apokyn
- apomorphine
- Aquachloral Supprettes
- aripiprazole
- Asendin
- Astramorph PF
- Atarax
- Ativan
- Aventyl HCl
- Avinza
- baclofen
- Banaril
- Banflex
- Banophen
- Beldin
- Belix
- Ben-Tann
- Benadryl
- Benadryl Allergy
- Benadryl Child Dye Free
- Benadryl Childrens Allergy Fastmelt
- Benadryl DF
- Benadryl Dye Free Allergy
- Benadryl Ultratab
- Benahist-10
- Benahist-50
- Benoject-50
- bromocriptine
- Budeprion SR
- Budeprion XL
- Buprenex
- Buprenorphine
- bupropion
- bupropion 24 hour extended release
- bupropion extended release
- Busodium
- BuSpar
- BuSpar Dividose
- buspirone
- butabarbital
- Butisol Sodium
- Bydramine
- cabergoline
- Calm-Aid
- Capoten
- captopril
- Carbacot
- Cathflo Activase
- Celexa
- cetirizine
- chloral hydrate
- chlordiazepoxide
- chlorpromazine
- chlorpromazine extended release
- citalopram
- clomipramine
- clonazepam
- Clopine
- clorazepate
- clorazepate extended release
- clozapine
- Clozapine Synthon
- Clozaril
- codeine
- codeine phosphate
- codeine sulfate
- Compazine
- Compazine Spansule
- Compoz Nighttime Sleep Aid
- Compro
- D.H.E. 45
- Dalmane
- Darvon
- Darvon-N
- Dazidox
- Demerol HCl
- Denzapine
- Desyrel
- Desyrel Dividose
- Diastat
- Diastat AcuDial
- Diastat Pediatric
- diazepam
- dihydrocodeine
- dihydroergotamine
- Dilaudid
- Dilaudid-5
- Dilaudid-HP
- Diphedryl
- Diphen
- Diphen AF
- Diphen Cough
- Diphenadryl
- Diphendryl
- Diphenhist
- diphenhydramine
- diphenhydramine citrate
- diphenhydramine tannate
- Diphenmax
- Diphenydramine Quick Melt
- Diphenyl
- Diphenylin
- Diskets
- Dizac
- Dolophine
- Doloral
- Doloral Sirop
- Doral
- Dostinex
- doxepin
- doxepin topical
- DPH
- Duragesic
- Duragesic-100
- Duragesic-12
- Duragesic-25
- Duragesic-50
- Duragesic-75
- Duramorph PF
- Dytan
- Dytuss
- Effexor
- Effexor XR
- Elavil
- enalapril
- enalaprilat
- Endep
- Endocodone
- Equanil
- Ergomar
- ergonovine
- ergotamine
- Ergotrate Maleate
- escitalopram
- ETH-Oxydose
- FazaClo
- fentanyl
- Fentora
- Flexoject
- Flexon
- fluoxetine
- fluoxetine extended release
- fluphenazine
- fluphenazine decanoate
- fluphenazine enanthate
- fluphenazine hydrochloride
- flurazepam
- fluvoxamine
- fluvoxamine extended release
- fosinopril
- Genahist
- Geodon
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- Hydramine
- Hydramine Compound
- Hydramine Cough Syrup
- Hydromorph Contin
- hydromorphone
- hydromorphone extended release
- Hydrostat IR
- hydroxyzine
- hydroxyzine hydrochloride
- hydroxyzine pamoate
- Hyrexin
- Hyzine
- iloprost
- imipramine
- imipramine pamoate
- Infumorph
- Invega
- Ionsys
- Kadian
- Klonopin
- Klonopin Wafer
- levocetirizine
- Levrix
- Lexapro
- Librium
- Lioresal
- Lioresal Intrathecal
- lisinopril
- lorazepam
- loxapine
- Loxitane
- Loxitane C
- Loxitane IM
- Ludiomil
- Luminal
- Luvox
- Luvox CR
- M-Eslon
- M-Oxy
- M. O. S.
- maprotiline
- maraviroc
- Mavik
- MB-TAB
- Mellaril
- Mellaril-S
- meperidine
- meprobamate
- methadone
- Methadose
- methdilazine
- Methergine
- methocarbamol
- methylergonovine
- methysergide maleate
- midazolam
- Migranal
- Miltown
- minoxidil topical
- Mio-Rel
- mirtazapine
- Mitran
- moexipril
- Monopril
- morphine
- morphine 24 hour extended release
- morphine extended release
- Morphine IR
- Morphine LP Epidural
- morphine preservative-free
- Morphine Rapi-Ject
- Morphitec
- MS
- MS Contin
- MS/S
- MSIR
- Myolin
- nalbuphine
- Natrecor
- nefazodone
- Nervine
- nesiritide
- Nightime Sleepaid
- Niravam
- Norflex
- Norflex Injectable
- nortriptyline
- Nu-Med
- Nubain
- Nytol Caplet
- olanzapine
- OMS
- opium
- Opium Deodorized
- Oramorph SR
- Orfro
- Ormazine
- orphenadrine
- orphenadrine extended release
- Orphenate
- oxazepam
- oxycodone
- oxycodone extended release
- OxyContin
- Oxyfast
- OxyIR
- paliperidone
- Palladone
- Palladone SR
- Pamelor
- Paral
- paraldehyde
- Pardryl
- Paregoric
- Parlodel
- paroxetine
- paroxetine extended release
- paroxetine mesylate
- Paxil
- Paxil CR
- Pentazine
- pentazocine
- Percolone
- perindopril
- Permitil
- perphenazine
- Pexeva
- Phenadoz
- Phenazine 50
- Phenergan
- Phenergan Fortis
- phenobarbital
- Phenoject-50
- PP-Cap
- Prinivil
- Pro-Med
- prochlorperazine
- prochlorperazine extended release
- Procot
- Prolixin
- Prolixin Decanoate
- Prolixin Enanthate
- Promacot
- promazine
- promethazine
- Promethegan
- propoxyphene
- propoxyphene hydrochloride
- propoxyphene napsylate
- Prorex
- Prozac
- Prozac Weekly
- Prudoxin
- Q-Dryl
- Q-Dryl A/F
- quazepam
- Quenalin
- quetiapine
- quetiapine extended release
- quinapril
- ramipril
- Rapiflux
- Remeron
- Remeron SolTab
- Rescudose
- Restoril
- Rezine
- Risperdal
- Risperdal Consta
- Risperdal M-Tab
- risperidone
- RMS
- Robaxin
- Robaxin-750
- Rogaine
- Rogaine Extra Strength
- Ronoxidil
- Roxanol
- Roxanol 100
- Roxanol-T
- Roxicodone
- Roxicodone Intensol
- Sansert
- Sarafem
- Scot-Tussin Allergy Relief Formula
- secobarbital
- Seconal Sodium
- Selzentry
- Serax
- Seroquel
- Seroquel XR
- sertraline
- Serzone
- Siladryl
- Siladryl DAS
- Siladyl SA
- Silphen Cough
- Simply Sleep
- Sinequan
- Skelex
- Sleep Tab II
- Sleep Tabs
- Sleep-ettes
- Sleep-Eze-3
- Sleepinal
- Solfoton
- Sominex
- Sominex Maximum Strength Caplet
- Somnicaps
- Somnote
- Sonata
- Sparine
- Statex
- Stelazine
- Sublimaze
- Subutex
- Surmontil
- Tacaryl
- Talwin Lactate
- temazepam
- Theraflu Thin Strips Multi Symptom
- thioridazine
- Thorazine
- tissue plasminogen activator
- Tofranil
- Tofranil-PM
- Total Allergy
- TPA
- trandolapril
- Tranxene SD
- Tranxene T-Tab
- trazodone
- Triaminic Thin Strips Cough & Runny Nose
- trifluoperazine
- Trilafon
- trimipramine
- Trux-adryl
- Tusstat
- Twilite
- Uni-Tann
- Unisom Sleepgels Maximum Strength
- Univasc
- Uprima
- V-Gan-25
- V-Gan-50
- Valium
- Valrelease
- Valu-Dryl
- Vanatrip
- Vasotec
- venlafaxine
- venlafaxine extended release
- Ventavis
- Versed
- verteporfin
- Vistacon
- Vistacot
- Vistaject-50
- Vistaril
- Vistaril IM
- Vistazine
- Vistazine 50
- Visudyne
- Wellbutrin
- Wellbutrin SR
- Wellbutrin XL
- Xanax
- Xanax XR
- Xyzal
- Xyzall
- zaleplon
- Zaponex
- Zestril
- Zetran
- ziprasidone
- Zoloft
- zolpidem
- zolpidem extended release
- Zonalon
- Zyban
- Zyban Advantage Pack
- Zyprexa
- Zyprexa Zydis
- Zyrtec
- Zyrtec Hives
Minor Interactions
- apraclonidine ophthalmic
- Atapryl
- Azilect
- Carbex
- Eldepryl
- Emsam
- furazolidone
- Furoxone
- Iopidine
- isocarboxazid
- Jumex
- linezolid
- Marplan
- Matulane
- Nardil
- omeprazole
- Parnate
- phenelzine
- Prilosec
- Prilosec OTC
- procarbazine
- rasagiline
- selegiline
- Selgene
- tranylcypromine
- Zegerid (Original Formulation)
- Zelapar
- Zyvox
LABORATORY TEST INTERACTIONS
Nitrates and nitrites may interfere with the Zlatkis-Zak color reaction, causing falsely low readings in serum cholesterol determinations.[1]
References
- ↑ "ISOSORBIDE MONONITRATE TABLET [ZYDUS PHARMACEUTICALS (USA) INC.]". Retrieved 30 January 2014.
Adapted from the FDA Package Insert.