Sumatriptan (oral)

Synonyms / Brand Names: Sumatriptan Succinate, Sumatriptanum, NP101, triptan, Imigran, Sumatran, Sumax, Imitrex

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Dosing and Administration

In controlled clinical trials, single doses of 5, 10, or 20 mg of Imitrex Nasal Spray administered into 1 nostril were effective for the acute treatment of migraine in adults. A greater proportion of patients had headache response following a 20-mg dose than following a 5- or 10-mg dose. Individuals may vary in response to doses of Imitrex Nasal Spray. The choice of dose should therefore be made on an individual basis, weighing the possible benefit of the 20-mg dose with the potential for a greater risk of adverse events. A 10-mg dose may be achieved by the administration of a single 5-mg dose in each nostril. There is evidence that doses above 20 mg do not provide a greater effect than 20 mg.
If the headache returns, the dose may be repeated once after 2 hours, not to exceed a total daily dose of 40 mg. The safety of treating an average of more than 4 headaches in a 30-day period has not been established.

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