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Stabilization phase (1-2 months): Transition when patient has: No withdrawal symptoms Minimal or no side effects No uncontrollable craving for opioid agonists Begin with buprenorphine/naloxone combination, increasing dose by 2/0.5-4/1 mg per week till stabilization is achieved, most stabilizing at 16/4-24/6 mg} As patient stabilizes, transition to alternate day or every third day regimen by doubling and tripling daily doses respectively