Delirium primary prevention

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vishal Khurana, M.B.B.S., M.D. [2]; Pratik Bahekar, MBBS [3]

Overview

Primary Prevention

It is important to prevent delirium as delirium is itself neurotoxic. It is associated with global brain atrophy and white matter disruption. Various pharmacological interventions have shown promising results in prevention of delirium, which are as follows,

• Post operative delirium,

  Haloperidol,

  Second-generation antipsychotics,

  Iliac fascia block,

  Gabapentin,

  Lower levels of intraoperative propofol sedation,

  A single dose of ketamine during anesthetic induction

• Mechanically ventilated medical and surgical ICU patients,

  Continuous intravenous infusion of dexmedetomidine

• Acutely ill general medical patients population,

  Melatonin