Thymoma historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Amr Marawan, M.D. [2]
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Historical Perspective
It has long been assumed that thymic epithelial cells originate from both the ectodermal and endodermal germ cell layers. However, a growing body of evidence suggests that the diverse thymic epithelial populations all develop from a common thymic epithelial stem cell of endodermal origin {181, 684}. This concept does not exclude the occurrence of more differentiated “committed stem cells” with medullary, cortical or other phenotypes {1671}. Tumours that we know as thymomas derive from thymic epithelium. In spite of morphological and immunological evidence for tumour differentiation towards a medullary or cortical epithelial phenotype, available data do not allow to unequivocally assign thymic tumours to defined functional and anatomical compartments of the normal thymus {1691}. [1]
References
- ↑ "http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/BB10.pdf" (PDF). External link in
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