Digoxin immune fab

Digoxin immune fab
Clinical data
Pregnancy; category	US: C (Risk not ruled out) ; ;
Routes of; administration	IV infusion, injection
ATC code	V03AB24 (WHO) ;
Pharmacokinetic data
Elimination half-life	15 hours for DigiFab, 23 hours for Digibind
Excretion	Renal
Identifiers
	IUPAC name Anti-digoxin antibody fragment;
DrugBank	BTD00027;
E number	{{#property:P628}}
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Chemical and physical data
Formula	C6394H9908N1698O2011S58
Molar mass	144602.257 g/mol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Digoxin Immune Fab (Ovine) is the generic name for an antidote for overdose of digitalis.^[1] It is made from immunoglobin fragments from sheep who have already been immunized with a digoxin derivative, digoxindicarboxymethoxylamine (DDMA). Its brand names include Digibind and DigiFab, with the former manufactured by GlaxoSmithKline and the latter manufactured by Protherics, Inc.

Pharmacology

It works by binding to the digoxin, rendering them unable to bind to their action sites on target cells. The complexes accumulate in the blood and are expelled by the kidney.

Contraindications

Although no contraindications have been noted, the patient must be closely monitored for anaphylactic shock, and anyone allergic to sheep protein, papain, bromelain, or papaya extracts (papain is used to cleave the antibody into Fab and Fc fragments) should not use Digoxin Immune Fab (Ovine). Because it is relatively new, no drug interaction studies have been performed yet.

References

↑ DiDomenico RJ, Walton SM, Sanoski CA, Bauman JL (2000). "Analysis of the use of digoxin immune fab for the treatment of non-life-threatening digoxin toxicity". J. Cardiovasc. Pharmacol. Ther. 5 (2): 77–85. PMID 11150387.

External links

de:Digitalis-Antidot

[pmid11150387-1] DiDomenico RJ, Walton SM, Sanoski CA, Bauman JL (2000). "Analysis of the use of digoxin immune fab for the treatment of non-life-threatening digoxin toxicity". J. Cardiovasc. Pharmacol. Ther. 5 (2): 77–85. PMID 11150387.

[1]