Cardioversion upto7 Days
| Drug | Route | Dosage |
|---|
| Dofetilide | Oral |
| Creatinine clearance(ml/min) | Dose (mg) |
|---|
| >60 | 500 |
| 40 to 60 | 250 |
| 20 to 40 | 125 |
| <20 | Contraindicated |
|
| Flecainide | Oral or
Intravenous | Oral: 200 to 300 mg
Intravenous: 1.5 to 3.0 mg/kg over 10 to 20 min |
| Ibutilide | Intravenous | 1 mg over 10 min; repeat 1 mg when necessary |
| Propafenone | Oral or
Intravenous | Oral: 600 mg
Intravenous: 1.5 to 2.0 mg/kg over 10 to 20 min |
| Amiodarone | Oral or
Intravenous | Oral:
- Inpatient: 1.2 to 1.8 g per day in divided dose until 10 g total
then 200 to 400 mg per day maintenance or 30 mg/kg as single dose
- Outpatient: 600 to 800 mg per day divided dose until 10 g total
then 200 to 400 mg per day maintenance.
Intravenous:
- 5 to 7 mg/kg over 30 to 60 min then 1.2 to 1.8 g per day continuous IV or
- in divided oral doses until 10 g total then 200 to 400 mg per day maintenance.
|
Cardioversion after 7 Days
| Drug | Route | Dosage |
|---|
| Dofetilide | Oral |
| Creatinine clearance(ml/min) | Dose (mg) |
|---|
| >60 | 500 |
| 40 to 60 | 250 |
| 20 to 40 | 125 |
| <20 | Contraindicated |
|
| Amiodarone | Oral or
Intravenous | Oral:
- Inpatient: 1.2 to 1.8 g per day in divided dose until 10 g total
then 200 to 400 mg per day maintenance or 30 mg/kg as single dose
- Outpatient: 600 to 800 mg per day divided dose until 10 g total
then 200 to 400 mg per day maintenance.
Intravenous:
- 5 to 7 mg/kg over 30 to 60 min then 1.2 to 1.8 g per day continuous IV or
- in divided oral doses until 10 g total then 200 to 400 mg per day maintenance.
|
| Ibutilide | Intravenous | 1 mg over 10 min; repeat 1 mg when necessary |
Drugs which enhance the efficacy of cardioversion when given prior to the procedure: (Level of recommendation: IIa B)
- Amiodarone
- Flecainide
- Ibutilide
- Propafenone
- Sotalol