Bivalirudin
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Jesus Rosario Hernandez, M.D. [2]
For patient information about Bivalirudin, click here.
Synonyms / Brand Names: ANGIOMAX®
Overview
Bivalirudin (Angiomax or Angiox, manufactured by The Medicines Company) is a specific and reversible direct thrombin inhibitor (DTI).[1]
Chemically, it is a synthetic congener of the naturally occurring drug hirudin (found in the saliva of the medicinal leech Hirudo medicinalis).
Bivalirudin is a DTI that overcomes many limitations seen with indirect thrombin inhibitors, such as heparin. Bivalirudin is a short, synthetic peptide that is potent, highly specific, and a reversible inhibitor of thrombin.[1][2][3] It inhibits both circulating and clot-bound thrombin,[3] while also inhibiting thrombin-mediated platelet activation and aggregation.[4] Bivalirudin has a quick onset of action and a short half-life.[1] It does not bind to plasma proteins (other than thrombin) or to red blood cells. Therefore it has a predictable antithrombotic response. There is no risk for Heparin Induced Thrombocytopenia/Heparin Induced Thrombosis-Thrombocytopenia Syndrome (HIT/HITTS).[1] It does not require a binding cofactor such as antithrombin and does not activate platelets.[2][5] These characteristics make bivalirudin an ideal alternative to heparin.
Bivalirudin clinical studies demonstrated consistent positive outcomes in patients with stable angina, unstable angina (UA), non-ST segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI) undergoing PCI in 7 major randomized trials.[1][3][4][6][7]
Category
FDA Package Insert
Label Title
Indications and Usage | Dosage and Administration | Dosage Forms and Strengths | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Use in Specific Populations | Overdosage | Description | Clinical Pharmacology | Nonclinical Toxicology | Clinical Studies | How Supplied/Storage and Handling | Patient Counseling Information | Labels and Packages
Mechanism of Action
References
- ↑ 1.0 1.1 1.2 1.3 1.4 "Angiomax (bivalirudin) Prescribing Information" (PDF). The Medicines Company. Retrieved 2 December 2011.[dead link]
- ↑ 2.0 2.1 PMID 17659921 (PMID 17659921)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ 3.0 3.1 3.2 PMID 2384594 (PMID 2384594)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ 4.0 4.1 PMID 17124018 (PMID 17124018)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ PMID 11967385 (PMID 11967385)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ PMID 11717596 (PMID 11717596)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ PMID 12588269 (PMID 12588269)
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