Metoprolol
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Clinical data | |
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Trade names | Lopressor, Toprol-xl |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682864 |
[[Regulation of therapeutic goods |Template:Engvar data]] |
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Routes of administration | Oral, IV |
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Pharmacokinetic data | |
Bioavailability | 12% |
Metabolism | Hepatic via CYP2D6, CYP3A4 |
Elimination half-life | 3-7 hours |
Excretion | Renal |
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E number | {{#property:P628}} |
ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
Chemical and physical data | |
Formula | C15H25NO3 |
Molar mass | 267.364 g/mol |
3D model (JSmol) | |
Melting point | 120 °C (248 °F) |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms / Brand Names: Lopressor, Toprol XL, Toprolxl XL
Overview
Metoprolol is a competitive, β1-selective (cardioselective) blocker used in treatment of angina pectoris, hypertension, arrhythmia, and migraine. Common adverse reactions include bradyarrhythmia, heart block, heart failure, hypotension, pruritus, rash, constipation, diarrhea, indigestion, nausea, dizziness, fatigue, headache, depression, dyspnea, and wheezing.
The active substance metoprolol is employed either as metoprolol succinate or as metoprolol tartrate (where 100 mg metoprolol tartrate corresponds to 95 mg metoprolol succinate). The tartrate is an immediate-release and the succinate is an extended-release formulation.[1]
Category
Anti-anginal, antiarrhythmic, beta-adrenergic blocker
Prescribing Information
Metoprolol Succinate
Metoprolol Succinate/Hydrochlorothiazide
Metoprolol Tartrate
Metoprolol Tartrate/Arginine
[[Metoprolol tartrate/Hydrochlorothiazide|Metoprolol Tartrate/ydrochlorothiazide
References
- ↑ Cupp M (2009). "Alternatives for Metoprolol Succinate" (pdf). Pharmacist's Letter / Prescriber's Letter. 25 (250302).