Carvedilol
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdurahman Khalil, M.D. [2]
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Overview
Carvedilol is an Alpha-adrenergic blocker, Beta-adrenergic blocker that is FDA approved for the {{{indicationType}}} of Heart failure of ischemic or cardiomyopathic origin, hypertension. Common adverse reactions include Fatigue, hypotension, dizziness, hyperglycemia.
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
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- Dosing Information
- (Dosage)
Off-Label Use and Dosage (Adult)
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
There is limited information regarding Carvedilol FDA-Labeled Indications and Dosage (Pediatric) in the drug label.
Off-Label Use and Dosage (Pediatric)
Contraindications
There is limited information regarding Carvedilol Contraindications in the drug label.
Warnings
There is limited information regarding Carvedilol Warnings' in the drug label.
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Carvedilol Clinical Trials Experience in the drug label.
Postmarketing Experience
There is limited information regarding Carvedilol Postmarketing Experience in the drug label.
Drug Interactions
There is limited information regarding Carvedilol Drug Interactions in the drug label.
Use in Specific Populations
Pregnancy
Pregnancy Category (FDA):
There is no FDA guidance on usage of Carvedilol in women who are pregnant.
Pregnancy Category (AUS):
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Carvedilol in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Carvedilol during labor and delivery.
Nursing Mothers
There is no FDA guidance on the use of Carvedilol in women who are nursing.
Pediatric Use
There is no FDA guidance on the use of Carvedilol in pediatric settings.
Geriatic Use
There is no FDA guidance on the use of Carvedilol in geriatric settings.
Gender
There is no FDA guidance on the use of Carvedilol with respect to specific gender populations.
Race
There is no FDA guidance on the use of Carvedilol with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Carvedilol in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Carvedilol in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Carvedilol in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Carvedilol in patients who are immunocompromised.
Administration and Monitoring
Administration
There is limited information regarding Carvedilol Administration in the drug label.
Monitoring
There is limited information regarding Carvedilol Monitoring in the drug label.
IV Compatibility
There is limited information regarding the compatibility of Carvedilol and IV administrations.
Overdosage
Acute Overdose
Signs and Symptoms
Overdosage may cause severe hypotension, bradycardia, cardiac insufficiency, cardiogenic shock, and cardiac arrest. Respiratory problems, bronchospasms, vomiting, lapses of consciousness, and generalized seizures may also occur.
Management
- The patient should be placed in a supine position and, where necessary and kept under observation
- The patient should be treated under intensive-care conditions.
- Gastric lavage or pharmacologically induced emesis may be used shortly after ingestion.
The following agents may be administered for excessive bradycardia:
- Atropine, 2 mg IV.
To support cardiovascular function:
- Glucagon, 5 to 10 mg IV rapidly over 30 seconds, followed by a continuous infusion of 5 mg/hour
- Sympathomimetics (dobutamine, isoprenaline, adrenaline) at doses according to body weight and effect.
- Glucagon, 5 to 10 mg IV rapidly over 30 seconds, followed by a continuous infusion of 5 mg/hour
If peripheral vasodilation dominates:
- Administer adrenaline ornoradrenaline with continuous monitoring of circulatory conditions.
For therapy-resistant bradycardia
- pacemaker therapy should be performed.
For bronchospasm
- β-sympathomimetics (as aerosol or IV) or Aminophylline IV should be given.
In the event of seizures
- Administer slow IV injection of diazepam or clonazepam is recommended.
NOTE: In the event of severe intoxication where there are symptoms of shock, treatment with antidotes must be continued for a sufficiently long period of time consistent with the 7-10 hour half-life of carvedilol.
Cases of overdosage with COREG alone or in combination with other drugs have been reported. Quantities ingested in some cases exceeded 1,000 milligrams. Symptoms experienced included low blood pressure and heart rate. Standard supportive treatment was provided and individuals recovered.
Pharmacology
There is limited information regarding Carvedilol Pharmacology in the drug label.
Mechanism of Action
There is limited information regarding Carvedilol Mechanism of Action in the drug label.
Structure
There is limited information regarding Carvedilol Structure in the drug label.
Pharmacodynamics
There is limited information regarding Carvedilol Pharmacodynamics in the drug label.
Pharmacokinetics
There is limited information regarding Carvedilol Pharmacokinetics in the drug label.
Nonclinical Toxicology
There is limited information regarding Carvedilol Nonclinical Toxicology in the drug label.
Clinical Studies
There is limited information regarding Carvedilol Clinical Studies in the drug label.
How Supplied
There is limited information regarding Carvedilol How Supplied in the drug label.
Storage
There is limited information regarding Carvedilol Storage in the drug label.
Images
Drug Images
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Package and Label Display Panel
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Patient Counseling Information
There is limited information regarding Carvedilol Patient Counseling Information in the drug label.
Precautions with Alcohol
Alcohol-Carvedilol interaction has not been established. Talk to your doctor regarding the effects of taking alcohol with this medication.
Brand Names
There is limited information regarding Carvedilol Brand Names in the drug label.
Look-Alike Drug Names
There is limited information regarding Carvedilol Look-Alike Drug Names in the drug label.
Drug Shortage Status
Price
References
The contents of this FDA label are provided by the National Library of Medicine.