Bumetanide (injection)
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]
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Black Box Warning
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WARNING
See full prescribing information for complete Boxed Warning.
Bumetanide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required, and dose and dosage schedule have to be adjusted to the individual patient’s needs (see DOSAGE AND ADMINISTRATION).
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Overview
Bumetanide (injection) is {{{aOrAn}}} loop diuretic that is FDA approved for the {{{indicationType}}} of edema associated with congestive heart failure, hepatic and renal disease, including the nephrotic syndrome,. There is a Black Box Warning for this drug as shown here. Common adverse reactions include Hypotension, hyperuricemia, hypochloremia, hypokalemia, nausea, cramp, dizziness, headache, azotemia.
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
Dosage should be individualized with careful monitoring of patient response.
Oral Administration
- Dosing Information
- Usual dosage: 0.5-2 mg PO qd {maximum daily dose of 10 mg}
Parenteral Administration
- Dosing Information
- usual initial dosage: 0.5 to 1 mg IV or IM
Off-Label Use and Dosage (Adult)
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
There is limited information regarding Bumetanide (injection) FDA-Labeled Indications and Dosage (Pediatric) in the drug label.
Off-Label Use and Dosage (Pediatric)
Contraindications
There is limited information regarding Bumetanide (injection) Contraindications in the drug label.
Warnings
|
WARNING
See full prescribing information for complete Boxed Warning.
Bumetanide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required, and dose and dosage schedule have to be adjusted to the individual patient’s needs (see DOSAGE AND ADMINISTRATION).
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There is limited information regarding Bumetanide (injection) Warnings' in the drug label.
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Bumetanide (injection) Clinical Trials Experience in the drug label.
Postmarketing Experience
There is limited information regarding Bumetanide (injection) Postmarketing Experience in the drug label.
Drug Interactions
There is limited information regarding Bumetanide (injection) Drug Interactions in the drug label.
Use in Specific Populations
Pregnancy
Pregnancy Category (FDA):
There is no FDA guidance on usage of Bumetanide (injection) in women who are pregnant.
Pregnancy Category (AUS):
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Bumetanide (injection) in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Bumetanide (injection) during labor and delivery.
Nursing Mothers
There is no FDA guidance on the use of Bumetanide (injection) in women who are nursing.
Pediatric Use
There is no FDA guidance on the use of Bumetanide (injection) in pediatric settings.
Geriatic Use
There is no FDA guidance on the use of Bumetanide (injection) in geriatric settings.
Gender
There is no FDA guidance on the use of Bumetanide (injection) with respect to specific gender populations.
Race
There is no FDA guidance on the use of Bumetanide (injection) with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Bumetanide (injection) in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Bumetanide (injection) in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Bumetanide (injection) in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Bumetanide (injection) in patients who are immunocompromised.
Administration and Monitoring
Administration
There is limited information regarding Bumetanide (injection) Administration in the drug label.
Monitoring
There is limited information regarding Bumetanide (injection) Monitoring in the drug label.
IV Compatibility
There is limited information regarding the compatibility of Bumetanide (injection) and IV administrations.
Overdosage
There is limited information regarding Bumetanide (injection) overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.
Pharmacology
There is limited information regarding Bumetanide (injection) Pharmacology in the drug label.
Mechanism of Action
There is limited information regarding Bumetanide (injection) Mechanism of Action in the drug label.
Structure
There is limited information regarding Bumetanide (injection) Structure in the drug label.
Pharmacodynamics
There is limited information regarding Bumetanide (injection) Pharmacodynamics in the drug label.
Pharmacokinetics
There is limited information regarding Bumetanide (injection) Pharmacokinetics in the drug label.
Nonclinical Toxicology
There is limited information regarding Bumetanide (injection) Nonclinical Toxicology in the drug label.
Clinical Studies
There is limited information regarding Bumetanide (injection) Clinical Studies in the drug label.
How Supplied
There is limited information regarding Bumetanide (injection) How Supplied in the drug label.
Storage
There is limited information regarding Bumetanide (injection) Storage in the drug label.
Images
Drug Images
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Package and Label Display Panel
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Patient Counseling Information
There is limited information regarding Bumetanide (injection) Patient Counseling Information in the drug label.
Precautions with Alcohol
Alcohol-Bumetanide (injection) interaction has not been established. Talk to your doctor regarding the effects of taking alcohol with this medication.
Brand Names
There is limited information regarding Bumetanide (injection) Brand Names in the drug label.
Look-Alike Drug Names
There is limited information regarding Bumetanide (injection) Look-Alike Drug Names in the drug label.
Drug Shortage Status
Price
References
The contents of this FDA label are provided by the National Library of Medicine.