Sandbox/00030
< Sandbox
| Site of Infection, by Severity or Extent | Route of Administration | Setting | Duration of Therapy | |
|---|---|---|---|---|
| Soft-tissue only | Mild (Grade 2) | Oral (or topical for superficial infections) | Outpatient | 1–2 wk |
| Moderate (Grade 3) | Oral (or initial parenteral) | Outpatient (or inpatient) | 1–3 wk | |
| Severe (Grade 4) | Initial parenteral, switch to oral when possible | Inpatient, then outpatient | 2–4 wk | |
| Bone or joint | No residual infected tissue | Parenteral or oral | Inpatient, then outpatient | 2–5 d |
| Residual infected soft tissue | Parenteral or oral | Inpatient, then outpatient | 1–3 wk | |
| Residual infected, viable bone | Initial parenteral, switch to oral when possible | Inpatient, then outpatient | 4–6 wk | |
| Residual dead bone or no surgery | Initial parenteral, switch to oral when possible | Inpatient, then outpatient | ≥3 mo | |