Peptic ulcer laboratory tests

Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing.

Peptic ulcer Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Peptic Ulcer from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Upper GI Endoscopy
X Ray
CT
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery Endoscopic management Surgical management
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
2017 ACG Guidelines for Peptic Ulcer Disease
Guidelines for the Indications to Test for, and to Treat, H. pylori Infection
Guidelines for First line Treatment Strategies of Peptic Ulcer Disease for Providers in North America
Guidlines for factors that predict the successful eradication when treating H. pylori infection
Guidelines to document H. pylori antimicrobial resistance in the North America
Guidelines for evaluation and testing of H. pylori antibiotic resistance
Guidelines for when to test for treatment success after H. pylori eradication therapy
Guidelines for penicillin allergy in patients with H. pylori infection
Guidelines for the salvage therapy
Peptic ulcer laboratory tests On the Web
Most recent articles
cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Peptic ulcer laboratory tests All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Peptic ulcer laboratory tests
CDC on Peptic ulcer laboratory tests
Peptic ulcer laboratory tests in the news
Blogs on Peptic ulcer laboratory tests
to Hospitals Treating Peptic ulcer
Risk calculators and risk factors for Peptic ulcer laboratory tests

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

• Etiological classification of peptic ulcers:
  • Positive for Helicobacter pylori infection.
  • Drug NSAID-induced.
  • H pylori and NSAIDs positive.
  • H pylori and NSAIDs negative (requires search for other causes).
• Approach of patients <55 years, depending of the Helicobacter pylori (H. pylori) prevalence (≥10%):
  • Test and treat for H. pylori using a validated noninvasive test and a trial of acid suppression if eradication is successful but symptoms do not resolve OR
  • Empiric trial of acid suppression with a proton pump inhibitor (PPI) for 4-8 weeks.

Laboratory Findings

The diagnosis of Helicobacter pylori can be by:

• Breath testing (does not require EGD);
• Direct culture from an EGD biopsy specimen;
• Direct detection of urease activity in a biopsy specimen;
• Measurement of antibody levels in blood (does not require EGD). It is still somewhat controversial whether a positive antibody without EGD is enough to warrant eradication therapy.

The possibility of other causes of ulcers, notably malignancy (gastric cancer) needs to be kept in mind. This is especially true in ulcers of the greater (large) curvature of the stomach; most are also a consequence of chronic H. pyloriinfection.