Neutropenia and Cellular Immune Deficient Patients
▸ Click on the following categories to expand treatment regimens.
Cellular Immune Deficiency
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Buccal Cellulitis (H. influenzae)
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Preferred Regimen
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▸ Ceftriaxone 1-2 g IV q24h
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Alternative Regimen
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▸ Meropenem 0.5-1 g IV q8h (infuse over 15-30 min or in bolus over 3-5 min) OR ▸ Imipenem/cilastatin 250-1000 mg IV (max: 50mg/kg/day)
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Adapted from N Engl J Med 2004;350:904-12.[1]
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Facial Cellulitis
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Preferred Regimen
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▸ Vancomycin 15-20 mg/kg IV q8-12h (trough 15—20 μg/mL)
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Alternative Regimen
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▸ Daptomycin 4 mg/kg IV q24h OR ▸ Linezolid 600mg IV q12h
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Salt Water Wound Exposure (Vibrio vulnificus)
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Preferred Regimen
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▸ Doxycycline 200 mg IV initial dose, then 50-100 mg IV q12h
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Alternative Regimen
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▸ Cefotaxime 1-2 g IV/IM q8-12 (up to 2 g q4-6h) OR ▸ Ciprofloxacin 400 mg IV q8-12h x 7-14 days OR ▸ Ciprofloxacin 500-750 mg PO q8-12h x 7-14 days
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Fresh Water Wound Exposure (Aeromonas spp)
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Preferred Regimen
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▸ Ciprofloxacin 400mg IV q12h OR ▸ Ceftazidime 0.5 -2 g IV q8h PLUS
▸ Gentamicin 3-5 mg/kg/day IV/IM divided q6-8h or 4-7 mg/kg IV q24h
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Alternative Regimen
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▸ Meropenem 0.5-1 g IV q8h (infuse over 15-30 min or in bolus over 3-5 min) OR ▸ Imipenem/cilastatin 250-1000 mg IV (max: 50mg/kg/day)
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Butcher, Fisherman, Veterinarian (Erysipelothrix rhusiopathiae)
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Preferred Regimen
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▸ Amoxicillin 500 mg PO q8hr
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Alternative Regimen
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▸ Cefotaxime 1-2 g IV/IM q8-12 (up to 2 g q4-6h) OR ▸ Ciprofloxacin 400 mg IV q8-12h x 7-14 days OR ▸ Ciprofloxacin 500-750 mg PO q8-12h x 7-14 days OR ▸ Imipenem-cilastatin 250-1000 mg IV (max: 50mg/kg/day)
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