Phenelzine
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]
Disclaimer
WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.
Black Box Warning
|
TITLE
See full prescribing information for complete Boxed Warning.
Condition Name: (Content)
|
Overview
Phenelzine is a MAOI that is FDA approved for the {{{indicationType}}} of depression-atypical, non-endogenous, or neurotic. There is a Black Box Warning for this drug as shown here. Common adverse reactions include orthostatic hypotension, weight gain, abdominal discomfort, constipation, xerostomia, increased liver aminotransferase level, without accompanying signs and symptoms, asthenia, dizziness, dyssomnia, headache, somnolence, disorder of ejaculation, impotence, orgasm incapacity,fatigue.
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
- Depression-atypical, non-endogenous, or neurotic
- Initial, 15 mg PO 3 times a day; increase to 60-90 mg/day
- Maintenance: after maximal therapeutic effect decrease dose slowly to the minimum effective dosage
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
There is limited information about Off-Label Guideline-Supported Use of Phenelzine in adult patients.
Non–Guideline-Supported Use
- Agoraphobia
- Bulimia nervosa
- 60-90 mg/day PO
- Panic disorder
- 15 mg PO for 4 days increase gradually over 2 weeks up to 15 mg 3-4 times a day.
- Social phobia
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
safety in children have not been established
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
There is limited information about Off-Label Guideline-Supported Use of Phenelzine in pediatric patients.
Non–Guideline-Supported Use
There is limited information about Off-Label Non–Guideline-Supported Use of Phenelzine in pediatric patients.
Contraindications
There is limited information regarding Phenelzine Contraindications in the drug label.
Warnings
|
TITLE
See full prescribing information for complete Boxed Warning.
Condition Name: (Content)
|
There is limited information regarding Phenelzine Warnings' in the drug label.
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Phenelzine Clinical Trials Experience in the drug label.
Postmarketing Experience
There is limited information regarding Phenelzine Postmarketing Experience in the drug label.
Drug Interactions
There is limited information regarding Phenelzine Drug Interactions in the drug label.
Use in Specific Populations
Pregnancy
Pregnancy Category (FDA):
There is no FDA guidance on usage of Phenelzine in women who are pregnant.
Pregnancy Category (AUS):
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Phenelzine in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Phenelzine during labor and delivery.
Nursing Mothers
There is no FDA guidance on the use of Phenelzine in women who are nursing.
Pediatric Use
There is no FDA guidance on the use of Phenelzine in pediatric settings.
Geriatic Use
There is no FDA guidance on the use of Phenelzine in geriatric settings.
Gender
There is no FDA guidance on the use of Phenelzine with respect to specific gender populations.
Race
There is no FDA guidance on the use of Phenelzine with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Phenelzine in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Phenelzine in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Phenelzine in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Phenelzine in patients who are immunocompromised.
Administration and Monitoring
Administration
There is limited information regarding Phenelzine Administration in the drug label.
Monitoring
There is limited information regarding Phenelzine Monitoring in the drug label.
IV Compatibility
There is limited information regarding the compatibility of Phenelzine and IV administrations.
Overdosage
There is limited information regarding Phenelzine overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.
Pharmacology
Mechanism of Action
There is limited information regarding Phenelzine Mechanism of Action in the drug label.
Structure
There is limited information regarding Phenelzine Structure in the drug label.
Pharmacodynamics
There is limited information regarding Phenelzine Pharmacodynamics in the drug label.
Pharmacokinetics
There is limited information regarding Phenelzine Pharmacokinetics in the drug label.
Nonclinical Toxicology
There is limited information regarding Phenelzine Nonclinical Toxicology in the drug label.
Clinical Studies
There is limited information regarding Phenelzine Clinical Studies in the drug label.
How Supplied
There is limited information regarding Phenelzine How Supplied in the drug label.
Storage
There is limited information regarding Phenelzine Storage in the drug label.
Images
Drug Images
{{#ask: Page Name::Phenelzine |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}
Package and Label Display Panel
{{#ask: Label Page::Phenelzine |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}
Patient Counseling Information
There is limited information regarding Phenelzine Patient Counseling Information in the drug label.
Precautions with Alcohol
Alcohol-Phenelzine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
Brand Names
There is limited information regarding Phenelzine Brand Names in the drug label.
Look-Alike Drug Names
There is limited information regarding Phenelzine Look-Alike Drug Names in the drug label.
Drug Shortage Status
Price
References
The contents of this FDA label are provided by the National Library of Medicine.
{{#subobject:
|Page Name=Phenelzine |Pill Name=No _image.jpg |Drug Name=Phenelzine |Pill Ingred=mannitol, silicon dioxide, povidone, edetate disodium, magnesium stearate, polyvinyl alcohol, polyethylene glycol 3350, fd&c yellow no. 6, talc, titanium dioxide|+sep=; |Pill Imprint=N/A |Pill Dosage=15.00 mg |Pill Color=Orange|+sep=; |Pill Shape=Round |Pill Size (mm)=261 |Pill Scoring=1 |Pill Image= |Drug Author=Novel Laboratories, Inc. |NDC=40032-360-21
}}
{{#subobject:
|Label Page=Phenelzine |Label Name=Phel1.PNG
}}
{{#subobject:
|Label Page=Phenelzine |Label Name=Phel2.PNG
}}