Enflurane
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]
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Overview
Enflurane is a general anesthetic that is FDA approved for the {{{indicationType}}} of analgesia for labor/delivery, For vaginal delivery, anesthesia - obstetric procedure, as supplement to other general anesthetic agents during cesarean section, general anesthesia.. Common adverse reactions include gastrointestinal: nausea, vomiting, musculoskeletal: involuntary movement, neurologic: shivering.
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
- Analgesia for labor/delivery, for vaginal delivery: for vaginal delivery, 0.25 to 1% concentration.
- Anesthesia - Obstetric procedure, As supplement to other general anesthetic agents during Cesarean section: during cesarean section, 0.5 to 1% concentration (to supplement other anesthetics).
- General anesthesia: induction, 2 to 4.5% concentration via vaporizer; with oxygen or combination with oxygen-nitrous oxide mixtures.
- General anesthesia: maintenance, 0.5 to 3% concentration; MAX 3%
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
- General anesthesia - Surgical procedure on eye proper
Non–Guideline-Supported Use
There is limited information about Off-Label Non–Guideline-Supported Use of Enflurane in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
There is limited information regarding Enflurane FDA-Labeled Indications and Dosage (Pediatric) in the drug label.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
There is limited information about Off-Label Guideline-Supported Use of Enflurane in pediatric patients.
Non–Guideline-Supported Use
There is limited information about Off-Label Non–Guideline-Supported Use of Enflurane in pediatric patients.
Contraindications
Seizure disorders (see WARNINGS) Known sensitivity to Enflurane or other halogenated anestheticsKnown or suspected genetic susceptibility to malignant hyperthermia
Warnings
There is limited information regarding Enflurane Warnings' in the drug label.
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Enflurane Clinical Trials Experience in the drug label.
Postmarketing Experience
There is limited information regarding Enflurane Postmarketing Experience in the drug label.
Drug Interactions
There is limited information regarding Enflurane Drug Interactions in the drug label.
Use in Specific Populations
Pregnancy
Pregnancy Category (FDA):
There is no FDA guidance on usage of Enflurane in women who are pregnant.
Pregnancy Category (AUS):
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Enflurane in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Enflurane during labor and delivery.
Nursing Mothers
There is no FDA guidance on the use of Enflurane in women who are nursing.
Pediatric Use
There is no FDA guidance on the use of Enflurane in pediatric settings.
Geriatic Use
There is no FDA guidance on the use of Enflurane in geriatric settings.
Gender
There is no FDA guidance on the use of Enflurane with respect to specific gender populations.
Race
There is no FDA guidance on the use of Enflurane with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Enflurane in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Enflurane in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Enflurane in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Enflurane in patients who are immunocompromised.
Administration and Monitoring
Administration
There is limited information regarding Enflurane Administration in the drug label.
Monitoring
There is limited information regarding Enflurane Monitoring in the drug label.
IV Compatibility
There is limited information regarding the compatibility of Enflurane and IV administrations.
Overdosage
There is limited information regarding Enflurane overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.
Pharmacology
There is limited information regarding Enflurane Pharmacology in the drug label.
Mechanism of Action
There is limited information regarding Enflurane Mechanism of Action in the drug label.
Structure
There is limited information regarding Enflurane Structure in the drug label.
Pharmacodynamics
There is limited information regarding Enflurane Pharmacodynamics in the drug label.
Pharmacokinetics
There is limited information regarding Enflurane Pharmacokinetics in the drug label.
Nonclinical Toxicology
There is limited information regarding Enflurane Nonclinical Toxicology in the drug label.
Clinical Studies
There is limited information regarding Enflurane Clinical Studies in the drug label.
How Supplied
There is limited information regarding Enflurane How Supplied in the drug label.
Storage
There is limited information regarding Enflurane Storage in the drug label.
Images
Drug Images
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Package and Label Display Panel
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Patient Counseling Information
There is limited information regarding Enflurane Patient Counseling Information in the drug label.
Precautions with Alcohol
Alcohol-Enflurane interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
Brand Names
There is limited information regarding Enflurane Brand Names in the drug label.
Look-Alike Drug Names
There is limited information regarding Enflurane Look-Alike Drug Names in the drug label.
Drug Shortage Status
Price
References
The contents of this FDA label are provided by the National Library of Medicine.