Proparacaine

Proparacaine

File:Proparacaine.png
Clinical data
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Topical
ATC code	N01BA04 (WHO)
Pharmacokinetic data
Bioavailability	n/a
Metabolism	plasma
Identifiers
IUPAC name 2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate
CAS Number	499-67-2
PubChem CID	10367247
DrugBank	APRD00522
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C16H26N2O3
Molar mass	294.389 g/mol

Proparacaine (Alcaine, Ak-Taine) is a topical anesthetic drug of the amino ester group. It is indicated for use as an ophthalmic anesthetic, to reduce pain and discomfort during procedures involving the eye. Proparacaine is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%. It is believed the drug exerts an effect on voltage gated sodium channels (as an antagonist) to affect the permeability of neuronal membranes; how this inhibits pain sensations and the exact mechanism of action of proparacaine are, however, unknown.