Dengue fever future or investigational therapies
Dengue Fever Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Dengue fever future or investigational therapies On the Web |
American Roentgen Ray Society Images of Dengue fever future or investigational therapies |
Dengue fever future or investigational therapies in the news |
Risk calculators and risk factors for Dengue fever future or investigational therapies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Although there is no commercially available vaccine, there are several ongoing vaccine development programs.
Vaccine development
There is no commercially available vaccine for the dengue flavivirus. A number of vaccine candidates are entering phase I or II testing.[1] Sanofi reported that its vaccine was effective in a late stage program. [2]
Inhibitors of Viral Replication
Emerging evidence suggests that mycophenolic acid and ribivirin inhibit Dengue fever virus replication. Initial experiments showed a fivefold increase in defective viral RNA production by cells treated with each drug.[2] In vivo studies, however, have not yet been done.
References
- ↑ Edelman R (2007). "Dengue vaccines approach the finish line". Clin Infect Dis. 45 (S1): S56&ndash, S60. doi:10.1086/518148.
- ↑ http://www.nytimes.com/2014/04/29/business/international/sanofi-says-dengue-vaccine-succeeds-in-late-stage-trial.html?_r=0