WBR0249

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Author [[PageAuthor::Rim Halaby, M.D. [1]]]
Exam Type ExamType::USMLE Step 1
Main Category MainCategory::Genetics
Sub Category SubCategory::Neurology
Prompt [[Prompt::A two year old male infant was brought by his mother to the pediatrician because she is feeling that her son is generally not doing fine. The mother has been noticing that the development of her child for the last few months is not the same as it was initially. The mother reports that the child is irritable most of the time, cries more than usual and is not growing well. Upon physical exam, the pediatrician notices that the infant's weight dropped outside his normal growth curve. In addition , abdominal swelling is noted. The pediatrician suspects the presence of an extracranial neurological malignancy that commonly occurs in the adrenal glands. Mutation in which of the following is associated with the patient's condition?]]
Answer A AnswerA::N-myc
Answer A Explanation [[AnswerAExp::N myc oncogene is associated with Neuroblastoma.]]
Answer B AnswerB::Ret
Answer B Explanation [[AnswerBExp::Ret oncogene is associated with MEN syndrome type IIa and IIb.]]
Answer C AnswerC::Abl
Answer C Explanation [[AnswerCExp::Abl oncogene is associated with CML.]]
Answer D AnswerD::L-myc
Answer D Explanation [[AnswerDExp::L-myc oncogene is associated with lung cancer.]]
Answer E AnswerE::C-myc
Answer E Explanation [[AnswerEExp::C-myc is associated with Burkitt's lymphoma.]]
Right Answer RightAnswer::A
Explanation [[Explanation::

Educational Objective:
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Approved Approved::No
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