Telmisartan detailed information

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Telmisartan detailed information
Clinical data
Pregnancy; category	D (Au), D (U.S.);
Routes of; administration	Oral
ATC code	C09CA07 (WHO) ;
Legal status
Legal status	S4 (Au), POM (UK), ℞-only (U.S.);
Pharmacokinetic data
Bioavailability	42–100%
Protein binding	≥99.5%
Metabolism	Minimal hepatic
Elimination half-life	24 hours
Excretion	Faecal 97%
Identifiers
	IUPAC name 2-[4-[[4-methyl-6-(1-methylbenzoimidazol-2-yl)-; 2-propyl-benzoimidazol-1-yl]methyl]phenyl]; benzoic acid;
CAS Number	144701-48-4;
PubChem CID	65999;
DrugBank	APRD01247;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C33H30N4O2
Molar mass	514.617 g/mol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Telmisartan (INN) (Template:PronEng) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. It is marketed under the trade names Micardis (Boehringer Ingelheim) and Pritor or Kinzal (Bayer Schering Pharma).

Pharmacology

Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT₁) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure.

New studies suggest that telmisartan may also have PPARγ agonistic properties that could potentially confer beneficial metabolic effects. This observation is currently being explored in clinical trials. In India it is available in the name of Telma by Glenmark Pharma according to www.sureshjain.com.

Clinical use

In India RANBAXY also markets it under the name of 'Teleact 20 mg"

External links

Template:Angiotensin II receptor antagonists

nl:Telmisartan

Template:WikiDoc Sources

Clinical data

Pregnancy category	D (Au), D (U.S.)
Routes of administration	Oral
ATC code	C09CA07 (WHO)
Legal status
Legal status	S4 (Au), POM (UK), ℞-only (U.S.)
Pharmacokinetic data
Bioavailability	42–100%
Protein binding	≥99.5%
Metabolism	Minimal hepatic
Elimination half-life	24 hours
Excretion	Faecal 97%
Identifiers
IUPAC name 2-[4-[[4-methyl-6-(1-methylbenzoimidazol-2-yl)- 2-propyl-benzoimidazol-1-yl]methyl]phenyl] benzoic acid
CAS Number	144701-48-4
PubChem CID	65999
DrugBank	APRD01247
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₃₃H₃₀N₄O₂
Molar mass	514.617 g/mol