Felodipine detailed information

Felodipine detailed information

Clinical data
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Oral
ATC code	C08CA02 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	>95%
Metabolism	Hepatic
Elimination half-life	??
Excretion	Renal
Identifiers
IUPAC name ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro -2,6-dimethyl-3,5- pyridinedicarboxylate
CAS Number	72509-76-3
PubChem CID	3333
DrugBank	APRD00374
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C18H19Cl2NO4
Molar mass	383.069 g/mol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Felodipine is a calcium channel blocker (calcium antagonist), a drug used to control hypertension (high blood pressure). It is marketed with the brand name Plendil by AstraZeneca.

Interactions

Recent findings have suggested that felodipine in combination with grapefruit juice can cause abnormal (toxic) effects. Oral administration of Felodipine is first metabolized in the gastrointestinal tract (GI) and liver by CYP3A4. Grapefruit juice is found to have an inhibiting effect over cytochrome P450 3A4. As a result the bioavailability of the drug and area under the curve (AUC) increase, increasing the risk for abnormal side effects. Therefore, special caution must be taken when mixing grapefruit juice with Felodipine.

References

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