Felodipine overdose
Overdosage topics
Animal data
Human experience
Symptoms
Severe hypotension
Hemodialysis
Treatment
Animal data
Oral doses of 240 mg/kg and 264 mg/kg in male and female mice, respectively, and 2390 mg/kg and 2250 mg/kg in male and female rats, respectively, caused significant lethality. Return to top
Human experience
In a suicide attempt, one patient took 150 mg Felodipine together with 15 tablets each of atenolol and spironolactone and 20 tablets of nitrazepam. The patient's blood pressure and heart rate were normal on admission to hospital; he subsequently recovered without significant sequelae. Return to top
Symptoms
Overdosage might be expected to cause excessive peripheral vasodilation with marked hypotension and possibly bradycardia. Return to top
Severe hypotension
If severe hypotension occurs, symptomatic treatment should be instituted. The patient should be placed supine with the legs elevated. The administration of intravenous fluids may be useful to treat hypotension due to overdosage with calcium antagonists. In case of accompanying bradycardia, atropine (0.5-1 mg) should be administered intravenously. Sympathomimetic drugs may also be given if the physician feels they are warranted. Return to top
Hemodialysis
It has not been established whether Felodipine can be removed from the circulation by hemodialysis. Return to top
Treatment
To obtain up-to-date information about the treatment of overdose, consult your Regional Poison-Control Center. Telephone numbers of certified poison-control centers are listed in the Physicians' Desk Reference (PDR). In managing overdose, consider the possibilities of multiple-drug overdoses, drug-drug interactions, and unusual drug kinetics in your patient. Return to top
Adapted from the FDA Package Insert.