Malaria laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]

Overview

The diagnosis of malaria is confimed by laboratory tests, which may reveal: anemia with decreased hemoglobin, hematocrit, haptoglobin and microcitosis; and leukocyte count, which may be elevated or decreased. Biochemistry may reveal hypoglycemia, elevated creatinine and LDH; acidosis expressed by an elevated lactate level and decreased bicarbonate level; and mild hyponatremia due to vomiting and diarrhea. In severe disease there may be some renal impairment, which will be expressed by proteinuria and hemoglobinuria.[1][2]

Laboratory Findings

Whenever possible, the diagnosis of malaria should be confirmed by laboratory tests.

The table below displays the nonspecific laboratory abnormalities associated with malaria:[1][3]

Laboratory findings
Test Findings
Complete Blood Count Decreased Hemoglobin
Decreased Hematocrit
Microcytosis
Decreased Haptoglobin
White blood cell count Elevated or Decreased Leukocyte Count
Biochemistry Hypoglycemia
Elevated Creatinine
Elevated LDH
Possible Hyponatremia
Acidosis: High Lactate; Low Bicarbonate
Coagulation Thrombocytopenia
Urinalysis Proteinuria
Hemoglobinuria


References

  1. 1.0 1.1 "Malaria".
  2. Mandell, Gerald (2010). Mandell, Douglas, and Bennett's principles and practice of infectious diseases. Philadelphia, PA: Churchill Livingstone/Elsevier. ISBN 0443068399.
  3. Mandell, Gerald (2010). Mandell, Douglas, and Bennett's principles and practice of infectious diseases. Philadelphia, PA: Churchill Livingstone/Elsevier. ISBN 0443068399.

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