Guanethidine

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Guanethidine
Clinical data
ATC code
Pharmacokinetic data
Elimination half-life1.5 days
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
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Chemical and physical data
FormulaC10H22N4
Molar mass198.309 g/mol

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as noradrenaline. Its mechanism is inhibition of the Mg++ATPase dependent pump. Side effects include orthostatic and exercise hypotension, sexual dysfunction, and diarrhea.

It is no longer available in the US due to side effects and because substantially better drugs are available. It is still licensed in some countries, e.g. UK, for the rapid control of blood pressure in a hypertensive emergency.