Yersinia pestis infection natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Serge Korjian, Yazan Daaboul
Overview
If plague patients are not administered specific antibiotic therapy, the disease can progress rapidly to death. Approximately 14% (1 in 7) of all plague cases in the United States are fatal.
Complications
| Bubonic Plague |
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| Septicemic Plague |
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| Pneumonic Plague |
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Prognosis
Despite being a treatable disease, plague is still associated with a high case fatality rate, often attributable to late recognition and inappropriate antibiotic therapy. Untreated bubonic plague has a case fatality of rate 50-60%, with proper identification and prompt treatment the case fatality decreases to around 7%.[3] Untreated septicemia or pneumonic plague is almost universally fatal if untreated early on. Even with proper therapy the latter may lead to mortality rates as high as 50%. [4]
References
- ↑ Koirala J (2006). "Plague: disease, management, and recognition of act of terrorism". Infect Dis Clin North Am. 20 (2): 273–87, viii. doi:10.1016/j.idc.2006.02.004. PMID 16762739.
- ↑ Koirala et al. Plague: disease, management, and recognition of act of terrorism. Infect Dis Clin N Am.2006;20:273-87
- ↑ "Human plague: review of regional morbidity and mortality, 2004-2009". Wkly Epidemiol Rec. 85 (6): 40–5. 2009. PMID 20151494.
- ↑ Dennis DT, Mead PS. Yersinia species, including plague. In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, Pa.: Elsevier Churchill-Livingstone; 2009:chap 229.