Bendroflumethiazide

Bendroflumethiazide

Clinical data
Pregnancy category	Risk neonatal thrombocytopenia in 3rd trimester
Routes of administration	oral
ATC code	C03AA01 (WHO)
Legal status
Legal status	UK: POM (Prescription only)
Pharmacokinetic data
Bioavailability	100%
Protein binding	96%
Metabolism	extensive
Elimination half-life	3-4 hours
Identifiers
IUPAC name 3-benzyl-5,5-dioxo-9- (trifluoromethyl)-5λ6- thia-2,4-diazabicyclo[4.4.0]deca-7, 9,11-triene-8-sulfonamide
CAS Number	73-48-3
PubChem CID	2315
DrugBank	APRD00666
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C15H14F3N3O4S2
Molar mass	421.417 g/mol

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List of terms related to Bendroflumethiazide

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Bendroflumethiazide (INN), formerly bendrofluazide (BAN), is a thiazide diuretic used to treat hypertension.

Bendroflumethiazide is a thiazide diuretic which works by inhibiting sodium reabsorption at the beginning of the distal convoluted tubule (DCT). Water is lost as a result of more sodium reaching the collecting ducts. Bendroflumethiazide has a role in the treatment of mild heart failure although loop diuretics are better for reducing overload. The main use of bendroflumethiazide currently is in hypertension (part of the effect is due to vasodilation).

Adverse Reactions

Common Adverse Effects

• postural hypotension
• Hyponatraemia, hypokalaemia, hypercalcaemia
• Gout
• Impaired glucose tolerance
• Impotence

Rare Adverse Effects

• Thrombocytopenia
• Agranulocytosis
• Photosensitivity rash
• Pancreatitis

Pill Images

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