Hepatitis D medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Varun Kumar, M.B.B.S. [2]; João André Alves Silva, M.D. [3] Jolanta Marszalek, M.D. [4]

Medical Therapy

Currently there is no effective antiviral therapy available for treatment of acute or chronic hepatitis D. The goal of treatment in hepatitis D is the clearance of the HDV and of the HBV helper virus. The complexity of the treatment resides in the need to address two viruses, and in the simplicity of the HDV, which limits the number of targets for therapeutic agents.

Liver transplantation has been helpful for treating fulminant acute and end-stage chronic hepatitis. In one study, the 5-year survival rate of transplant patients for terminal delta cirrhosis was 88% with reappearance of HBsAg only in 9% under long-term anti-HBs prophylaxis.