West nile virus future or investigational therapies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]

Overview

Ribavirin and interferon alfa-2b are currently being studied for the treatment of west nile virus CNS infection, as both drugs have shown benefit in in vitro studies.

Future or Investigational Therapies

Vaccine

^[1]

Medications

Ribavirin has been used in cases of west nile virus CNS involvement, as it has demonstrated inhibition of the virus in human neural cells in vitro.^[2]^[3]
Interferon alfa-2b has also shown benefit in in vitro studies against west nile virus CNS infection.^[4]
Further studies need to be done to determine the efficacy and safety of ribavirin and interferon alfa-2b in west nile virus infection.

References

↑ Brandler, Samantha; Tangy, Frederic (2013). "Vaccines in Development against West Nile Virus". Viruses. 5 (10): 2384–2409. doi:10.3390/v5102384. ISSN 1999-4915.
↑ I. Jordan, T. Briese, N. Fischer, J. Y. Lau & W. I. Lipkin (2000). "Ribavirin inhibits West Nile virus replication and cytopathic effect in neural cells". The Journal of infectious diseases. 182 (4): 1214–1217. doi:10.1086/315847. PMID 10979920. Unknown parameter |month= ignored (help)
↑ S. Ia Loginova, S. V. Borisevich, Iu A. Pashchenko & V. P. Bondarev (2009). "[Ribavirin prophylaxis and therapy of experimental West Nile fever]". [[Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoi i mikrobiologicheskoi promyshlennosti SSSR]]. 54 (11–12): 17–20. PMID 20583562.
↑ Anderson, John F. (2002). "Efficacy of Interferon -2b and Ribavirin Against West Nile Virus In Vitro". Emerging Infectious Diseases. 8 (1): 107–108. doi:10.3201/eid0801.010252. ISSN 1080-6040.

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[BrandlerTangy2013-1] Brandler, Samantha; Tangy, Frederic (2013). "Vaccines in Development against West Nile Virus". Viruses. 5 (10): 2384–2409. doi:10.3390/v5102384. ISSN 1999-4915.

[2] I. Jordan, T. Briese, N. Fischer, J. Y. Lau & W. I. Lipkin (2000). "Ribavirin inhibits West Nile virus replication and cytopathic effect in neural cells". The Journal of infectious diseases. 182 (4): 1214–1217. doi:10.1086/315847. PMID 10979920. Unknown parameter |month= ignored (help)

[3] S. Ia Loginova, S. V. Borisevich, Iu A. Pashchenko & V. P. Bondarev (2009). "[Ribavirin prophylaxis and therapy of experimental West Nile fever]". [[Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoi i mikrobiologicheskoi promyshlennosti SSSR]]. 54 (11–12): 17–20. PMID 20583562.

[Anderson2002-4] Anderson, John F. (2002). "Efficacy of Interferon -2b and Ribavirin Against West Nile Virus In Vitro". Emerging Infectious Diseases. 8 (1): 107–108. doi:10.3201/eid0801.010252. ISSN 1080-6040.

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