Low density lipoprotein historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Rim Halaby, M.D. [3]
Overview
Historical Perspective
- In 1949, a new method for quantitative measurement of LDL and other lipoproteins using ultracentrifuge was developed.[1]
- In 1950, LDL was first isolated.[2]
- In 1963, another lipoprotein, Lp(a), was discovered as a complex particle in human plasma in an immunochemical study.[3]
- In 1973, Myant first hypothesized the role of LDL in the metabolism of cholesterol.[4]
- In 1979, the Lipid Research Clinics Coronary Primary Prevention Trial (LRC-CPPT) demonstrated that reductions in total cholesterol and LDL were associated with reduction in CHD risk. It was reported that a 25% reduction in cholesterol or a 35% reduction in LDL cholesterol resulted in a 49% decrease in CHD risk.[5][6]
References
- ↑ GOFMAN, JW.; LINDGREN, FT.; ELLIOTT, H. (1949). "Ultracentrifugal studies of lipoproteins of human serum". J Biol Chem. 179 (2): 973–9. PMID 18150027. Unknown parameter
|month=ignored (help) - ↑ "http://dx.doi.org/10.1021/ja01157a121". Retrieved 8 November 2013. External link in
|title=(help) - ↑ BERG, K. (1963). "A NEW SERUM TYPE SYSTEM IN MAN--THE LP SYSTEM". Acta Pathol Microbiol Scand. 59: 369–82. PMID 14064818.
- ↑ Myant NB (1973). "Cholesterol metabolism". J Clin Pathol Suppl (Assoc Clin Pathol). 5: 1–4. PMC 1436101. PMID 4354844.
- ↑ "Plasma lipid distributions in selected North American populations: the Lipid Research Clinics Program Prevalence Study. The Lipid Research Clinics Program Epidemiology Committee". Circulation. 60 (2): 427–39. 1979. PMID 312704. Unknown parameter
|month=ignored (help) - ↑ "The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease". JAMA. 251 (3): 351–64. 1984. PMID 6361299. Unknown parameter
|month=ignored (help)