Low density lipoprotein screening
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [5]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [6]
Overview
According to the United States Preventive Services Task Force (USPSTF), screening for high LDL-cholesterol (LDL-c), is indicated among men 35 years and older (Grade: A Recommendation), men age 20 to 35 years in case of an elevated risk for coronary heart disease (Grade: B Recommendation), women age 45 years and older for in case of an elevated risk for coronary heart disease (Grade: A Recommendation), and women age 20 to 45 years in case of an elevated risk for coronary heart disease (Grade: B Recommendation).[1] There is insufficient evidence to recommend for or against screening for dyslipidemia among infants, children, adolescents, or young adults less than 20 years of age (Grade: I statement).[2]
Screening
Screening Indications
Screening in Adults
Screening for dyslipidemia, including high LDL, depends on the gender, age, and the risk for coronary heart disease. Screening for high HDL is indicated among the following:[3]
- Men 35 years and older (Grade: A Recommendation)
- Men 20 to 35 years in case of an elevated risk for coronary heart disease (Grade: B Recommendation)
- Women 45 years and older for in case of an elevated risk for coronary heart disease (Grade: A Recommendation)
- Women 20 to 45 years in case of an elevated risk for coronary heart disease (Grade: B Recommendation)
Screening in Children
There is insufficient evidence to recommend for or against screening for dyslipidemia among infants, children, adolescents, or young adults less than 20 years of age (Grade: I statement).[4]
Screening Components
Screening for high LDL includes:[5]
- Identification of risk factors for coronary artery disease
- Estimation of the 10-year risk of cardiovascular disease
- Measurement of fasting lipid panel (total cholesterol, LDL, HDL, triglycerides)
References
- ↑ Screening for Lipid Disorders in Adults, Topic Page. U.S. Preventive Services Task Force. [1]
- ↑ U.S. Preventive Services Task Force. Screening for Lipid Disorders in Children: Recommendation Statement. July 2007.[2]
- ↑ Screening for Lipid Disorders in Adults, Topic Page. U.S. Preventive Services Task Force. [3]
- ↑ U.S. Preventive Services Task Force. Screening for Lipid Disorders in Children: Recommendation Statement. July 2007.[4]
- ↑ Jellinger PS, Smith DA, Mehta AE, Ganda O, Handelsman Y, Rodbard HW; et al. (2012). "American Association of Clinical Endocrinologists' Guidelines for Management of Dyslipidemia and Prevention of Atherosclerosis: executive summary". Endocr Pract. 18 (2): 269–93. PMID 22507559.