Dilated cardiomyopathy causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sachin Shah, M.D. Ogheneochuko Ajari, MB.BS, MS [2]
Overview
There are many causes of dilated cardiomyopathy. The most common cause is idiopathic in 50% of cases. The next most common cause is myocarditis which is responsible for 10% of cases. The high percentage of idiopathic dilated cardiomyopathy may be related to the difficulty in diagnosing viral myocarditis. Other common causes include substance abuse, connective tissue disease, pregnancy, medications, nutritional deficiencies, infiltrative diseases and toxins. There are varying degrees of severity of the disease. Some forms are reversible and some are irreversible; some patients may be completely asymptomatic and some may require cardiac transplantation.
Causes
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
Common Causes
- Antiretroviral drugs
- Chemotherapeutic agents (such as Doxorubicin)
- Connective tissue disease
- Eosinophilic cardiomyopathy
- Hemochromatosis
- HIV infection
- Hypertensive heart disease
- Idiopathic [1]
- Ischemic cardiomyopathy
- Myocarditis
- Nutritional deficiencies (such as thiamine or selenium)
- Peripartum cardiomyopathy
- Sarcoidosis
- Sleep apnea
- Substance abuse (alcohol abuse or cocaine abuse)
- Toxins (such as cobalt, lead or beryllium)
Causes by Organ System
Causes in Alphabetical Order
- Acromegaly
- Adenovirus
- Adriamycin
- Alcohol abuse
- Alström syndrome
- Amphetamines
- Amyloidosis
- Anthracyclines
- Antiretroviral drugs
- Barth syndrome
- Becker muscular dystrophy
- Beriberi
- Beryllium
- Bleomycin
- Brucellosis
- Carbon monoxide poisoning
- Carnitine
- Carvajal-Huerta syndrome
- Certolizumab pegol
- Chagas disease
- Chemotherapeutic agents
- Childbirth
- Chloroquine
- Clozapine
- Cobalt
- Cocaine
- Connective tissue disease
- Coronary artery disease
- Coxsackie virus
- Cryptococcosis
- Cushing's syndrome
- Cyclophosphamide
- Cytomegalovirus
- Dermatomyositis
- Desmin-related myopathy
- Diabetes mellitus
- Didanosine
- Diphtheria
- Disopyramide
- Doxorubicin
- Duchenne's muscular dystrophy
- Echovirus
- Electric shock
- Emery-Dreifuss muscular dystrophy, X-linked
- Endocardial fibroelastosis
- Epirubicin
- Epstein-Barr virus
- Erb dystrophy
- Ethanol
- Fabry's disease
- Familial cutaneous collagenoma
- Friedreich's ataxia
- Giant cell arteritis
- Glycogenosis type 2b
- Heat stroke
- Heavy metals
- Hemochromatosis
- Hepatitis
- Histoplasmosis
- HIV infection
- Hyperparathyroidism
- Hypersensitivity myocarditis
- Hypertension
- Hypertensive heart disease
- Hypocalcemia
- Hypoparathyroidism
- Hypophosphatemia
- Hypothermia
- Hypothyroidism
- Idarubicin
- Idiopathic
- Imatinib mesylate
- Influenza virus
- Ischemic heart disease
- Ischemic cardiomyopathy
- Isobutyryl-CoA dehydrogenase deficiency
- Kawasaki disease
- Laing distal myopathy
- Lead
- Leptospirosis
- Limb girdle muscular dystrophy
- Lithium
- Loa loa
- Lyme disease
- McLeod neuroacanthocytosis syndrome
- McLeod phenotype
- Mercury
- Methysergide
- Mitoxantrone
- Myocarditis
- Myotonic dystrophy
- Myxedema
- Myxoma
- Naxos disease
- Niacin
- Nutritional deficiencies
- Paracetamol
- Parvovirus
- Pellagra
- Peplomycin
- Peripartum cardiomyopathy
- Phenothiazines
- Pheochromocytoma
- Pituitary tumor
- Pregnancy
- Psittacosis
- Radiation
- Refsum's disease
- Rheumatic fever
- Rheumatoid arthritis
- Salih myopathy
- Sarcoidosis
- Scleroderma
- Selenium deficiency
- Serum sickness
- Schistosomiasis
- Sleep apnea
- Substance abuse
- Systemic lupus erythematosis
- Tachycardia
- Tacrolimus
- Thiamine
- Toxins
- Toxoplasmosis
- Transplant rejection
- Trastuzumab
- Trichinosis
- Triosephosphate isomerase deficiency
- Trypanosomiasis
- Typhoid fever
- Uremia
- Varicella
- Whipple's disease
- X-linked dilated cardiomyopathy
- Zalcitabine
- Zidovudine
References
- ↑ Felker GM, Thompson RE, et al. Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy. N Engl J Med 2000 Apr 13;342(14):1077-84.