Major or mild neurocognitive disorder due to Parkinson's disease

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

Major or Mild Neurocognitive Disorder Due to Parkinson's Disease

DSM-V Diagnostic Criteria for Major or Mild Neurocognitive Disorder Due to Parkinson's Disease

“

A.The criteria are met for major or mild neurocognitive disorder. AND B.The disturbance occurs in the setting of established Parkinson’s disease. AND C.There is insidious onset and gradual progression of impairment. AND D.The neurocognitive disorder is not attributable to another medical condition and is not better explained by another mental disorder. Major or mild neurocognitive disorder probably due to Parkinson’s disease should be diagnosed if 1 and 2 are both met. Major or mild neurocognitive disorder possibly due to Parkinson’s disease should be diagnosed if 1 or 2 is met: 1.There is no evidence of mixed etiology (i.e., absence of other neurodegenerative or cerebrovascular disease or another neurological, mental, or systemic disease or condition likely contributing to cognitive decline). 2.The Parkinson’s disease clearly precedes the onset of the neurocognitive disorder.

”

Epidemiology and Demographics

Prevalence

The prevalence of major or mild neurocognitive disorder due to parkinson's disease is:

75,000 per 100,000 (75%) major neurocognitive disorder.

27,000 per 100,000 (27%) mild neurocognitive disorder.

Risk Factors

• Herbicides
• Increasing duration of disease
• Older age at disease onset
• Pesticides

Differential Diagnosis

• Major or mild neurocognitive disorder due to Alzheimer’s disease
• Major or mild neurocognitive disorder with Lewy bodies
• Major or mild vascular neurocognitive disorder
• Neurocognitive disorder due to another medical condition (e.g., neurodegenerative disorders)

• Corticobasal degeneration
• Hydrocephalus
• Multiple system atrophy
• Progressive supranuclear palsy
• Tumors

• Neuroleptic-induced parkinsonism
• Other medical conditions

• B12 deficiency
• Delirium
• Hypothyroidism
• Impaired cognition
• Side effects of dopamine-blocking drugs
• Sedation