Hyaluronic acid (topical)

Hyaluronic acid (topical)
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

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Overview

Hyaluronic acid (topical) is a musculoskeletal agent that is FDA approved for the treatment of {{{indication}}}. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indications

Hyaluronic Acid Solution

• For hair grower and loss prevention

Dosage

• Spray on the scalp 2~3 times daily as needed
• Recommendable to apply enough on the scalp prior to going to bed

Hyaluronic Acid Injection

• Osteoarthritis of knee

Dosage

• Osteoarthritis of knee: 30 mg per 2 mL (contents of prefilled syringe) INTRA-ARTICULARLY into the knee once weekly for a total of 3 to 4 injections (as a series of 3 to 4 injections each 1 week apart).

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Hyaluronic acid (topical) in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Hyaluronic acid (topical) in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding FDA-Labeled Use of Hyaluronic acid (topical) in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1

• Developed by:

• Class of Recommendation:

• Strength of Evidence:

• Dosing Information

• Dosage

Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Hyaluronic acid (topical) in pediatric patients.

Non–Guideline-Supported Use

Condition1

• Dosing Information

• Dosage

Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Hyaluronic acid (topical) in pediatric patients.

Contraindications

There is limited information regarding Hyaluronic acid (topical) Contraindications in the drug label.

Warnings

• Stop using and see a doctor if any hypersensitivity symptom continues
• Avoid storing under direct sung light or high temperature

Adverse Reactions

Clinical Trials Experience

Dermatologic: Injection site pain (2.5% ), Injection site reaction (0.2% )

Musculoskeletal: Arthralgia (12.6% )

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Hyaluronic acid (topical) in the drug label.

Drug Interactions

• Drug

• Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

• Pregnancy Category

Pregnancy Category (AUS):

• Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Hyaluronic acid (topical) in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Hyaluronic acid (topical) during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Hyaluronic acid (topical) with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Hyaluronic acid (topical) with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Hyaluronic acid (topical) with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Hyaluronic acid (topical) with respect to specific gender populations.

Race

There is no FDA guidance on the use of Hyaluronic acid (topical) with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Hyaluronic acid (topical) in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Hyaluronic acid (topical) in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Hyaluronic acid (topical) in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Hyaluronic acid (topical) in patients who are immunocompromised.

Administration and Monitoring

Administration

• IV

Intra-articular

Attach a small gauge needle (18- to 21-gauge) to tip of the syringe; inject the full contents of syringe into one knee only.

If treatment is bilateral, use a separate syringe for each knee.

• For hair scalp spraying only

Monitoring

• Reduction in pain associated with osteoarthritis of the knee is indicative of efficacy

IV Compatibility

There is limited information regarding IV Compatibility of Hyaluronic acid (topical) in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

• Description

Management

• Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Hyaluronic acid (topical) in the drug label.

Pharmacology

There is limited information regarding Hyaluronic acid (topical) Pharmacology in the drug label.

Mechanism of Action

Structure

File:Hyaluronic acid (topical)01.png

This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Hyaluronic acid (topical) in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Hyaluronic acid (topical) in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Hyaluronic acid (topical) in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Hyaluronic acid (topical) in the drug label.

How Supplied

Storage

There is limited information regarding Hyaluronic acid (topical) Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Patient Counseling Information of Hyaluronic acid (topical) in the drug label.

Precautions with Alcohol

• Alcohol-Hyaluronic acid (topical) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

• ®

Look-Alike Drug Names

• A® — B®

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

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