Osteonecrosis of the jaw historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
ONJ is not a new disease, around 1850 various forms of "chemical osteomyelitis" resulting from environmental pollutants, such as lead and the white phosphorus used in early (non-safety) matches (Phossy jaw), as well as from popular medications containing mercury, arsenic or bismuth, were reported in the literature.[1][2][3][4][5][6][7] This disease apparently did not often occur in individuals with good gingival health, and usually targeted the mandible first.[2]It was associated with localized or generalized deep ache or pain, often of multiple jawbone sites. The teeth often appeared sound and suppuration was not present. Even so, the dentist often began extracting one tooth after another in the region of pain, often with temporary relief but usually to no real effect.[3] A growing body of scientific evidence indicate that this disease process, in the cancellous bone and bone marrow, is caused by bone infarcts mediated by a range of local and systemic factors. In the modern dental profession, it is only recently when severe cases associated with bisphosphonates came to light, that the issue of ONJ has been brought to the attention of a majority of dentists. At present, the focus is mostly on bisphosphonates associated cases, and is sometimes referred to colloquially as "phossy jaw", a similar, earlier occupational disease.[8][9]
References
- ↑ Bond TE Jr. A practical treatise on dental medicine. Philadelphia: Lindsay & Blakiston, 1848.
- ↑ 2.0 2.1 Anonymous. Necrosis of the lower jaw in makers of Lucifer matches. Am J Dent Science 1867; 1 (series 3):96-97.
- ↑ 3.0 3.1 Bouquot J.E. The history of maxillofacial osteonecrosis. Maxillofacial Center for Diagnostics and Research. Accessed 22 May 2006.
- ↑ Ferguson W. New treatment of necrosis. Am J Dent Science 1868; 1 (series 3):189.
- ↑ Noel HR. A lecture on caries and necrosis of bone. Am J Dent Science 1868; 1 (series 3):425, 482.
- ↑ Barrett WC. Oral pathology and practice. Philadelphia, S.S. White Dental Mfg Co, 1898.
- ↑ Black GV. A work on special dental pathology (2nd ed). Chicago, Medico_Dental Publ Co, 1915
- ↑ PM Purcell, IW Boyd, Bisphosphonates and osteonecrosis of the jaw, ADRAC Report, MJA 2005; 182 (8): 417-418
- ↑ J Carreyrou, Fosamax Drug Could Become Next Merck Woe, Dow Jones (THE WALL STREET JOURNAL), Apr. 12, 2006