Bone marrow disorders
For congenital bone marrow disorders click here.
For acquired bone marrow disorders click here.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]; Yazan Daaboul, M.D.; Serge Korjian M.D.
Overview
Bone marrow disorders are classified into congenital bone marrow disorders and acquired bone marrow disorders.
Definition of Terms
- Bone marrow suppression: Reduced numbers of cells in bone marrow
- Myelosuppression: Reduced number of myeloid lineage cells (RBC, neutrophils, basophils, eosinophils, monocytes, platelets, mastocytes)
- Immunosuppression or lymphosuppression: Reduced number of lymphoid lineage cells (T-cell, B-cell, NK cell)
- Bone marrow proliferation: Increased numbers of cells in bone marrow
- Myeloproliferation: Increased number of myeloid lineage cells (RBC, neutrophils, basophils, eosinophils, monocytes, platelets, mastocytes)
- Immunoproliferation or lymphoproliferation: Increased number of lymphoid lineage cells (T-cell, B-cell, NK cell)
Classification
Shown below is an algorithm depicting the different classes of bone marrow disorders.
| Bone Marrow Disorders | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Myelosuppression | Immunosuppression | Myeloproliferation | Immunoproliferation | Multiple lineages | Single lineage | ||||||||||||||||||||||||||||||||||||||||||||||