Febrile neutropenia physical examination
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: F and N; fever and neutropenia; FN; hot and low; hot leuk; neutropenic fever; neutropenic fever syndrome; neutropenic sepsis
Overview
The physical examination should focus on potential sites of infection.
Physical Examination
Skin
Induration and erythema may be minimal. Pustule formation are uncommon in the absence of neutrophils.
Throat
Examination of the oropharynx may reveal ulcers or plaques suggestive of herpes or candidiasis. Mucositis owing to cytotoxic chemotherapy may be indistinguishable from herpetic gingivostomatitis.
Lungs
Auscultation of the lungs may reveal minimal adventitial sounds.
Abdomen
Abdominal pain in neutropenic patients may herald an intraabdominal catastrophe secondary to neutropenic enterocolitis or tumor necrosis.
Other
Examination of catheter sites may disclose erythema, tenderness, or discharge.