GRADE system classification scheme
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Grading of Recommendations Assessment, Development and Evaluation (GRADE) system was developed to guide assessment of quality of evidence from high (A) to very low (D) and to determine the strength of recommendations as strong (1) or weak (2).
Levels of Evidence[1]
| Quality of evidence | Definition |
|---|---|
| High quality (Grade A) | Further research is very unlikely to change our confidence in the estimate of effect. |
| Moderate quality (Grade B) | Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. |
| Low quality (Grade C) | Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. |
| Very low quality (Grade D) | Any estimate of effect is very uncertain. |
References
- ↑ Guyatt, GH.; Oxman, AD.; Vist, GE.; Kunz, R.; Falck-Ytter, Y.; Alonso-Coello, P.; Schünemann, HJ.; Alderson, P.; Alonso-Coello, P. (2008). "GRADE: an emerging consensus on rating quality of evidence and strength of recommendations". BMJ. 336 (7650): 924–6. doi:10.1136/bmj.39489.470347.AD. PMID 18436948. Unknown parameter
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