Methyldopate

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Methyldopate
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Adeel Jamil, M.D. [2]

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Overview

Methyldopate is an antihypertensive agent that is FDA approved for the treatment of hypertension, when parenteral medication is indicated. Common adverse reactions include drowsiness, sedation, headache and asthenia.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

  • Hypertension, when parenteral medication is indicated. The treatment of hypertensive crises may be initiated with Methyldopate HCl Injection.

Dosing Information

  • Methyldopate HCl Injection when given intravenously in effective doses, causes a decline in blood pressure that may begin in four to six hours and last 10 to 16 hours after injection.
  • Add the desired dose of Methyldopate HCl Injection to 100 mL of Dextrose Injection 5%, USP. Alternatively the desired dose may be given in 5% dextrose in water in a concentration of 100 mg/10 mL. Give this intravenous infusion slowly over a period of 30 to 60 minutes.
  • The usual adult dosage intravenously is 250 mg to 500 mg at six hour intervals as required. The maximum recommended intravenous dose is 1 gram every six hours.
  • When control has been obtained, oral therapy with tablets may be substituted for intravenous therapy, starting with the same dosage schedule used for the parenteral route. The effectiveness and anticipated responses are described in the circular for tablets.
  • Since methyldopate has a relatively short duration of action, withdrawal is followed by return of hypertension usually within 48 hours. This is not complicated by an overshoot of blood pressure.
  • Occasionally tolerance may occur, usually between the second and third month of therapy. Adding a diuretic or increasing the dosage of methyldopa frequently will restore effective control of blood pressure. A thiazide may be added at any time during methyldopa therapy and is recommended if therapy has not been started with a thiazide or if effective control of blood pressure cannot be maintained on 2 grams of methyldopa daily.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Methyldopate in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Methyldopate in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Dosing Information

  • The recommended daily dosage is 20 to 40 mg/kg of body weight in divided doses every six hours. The maximum dosage is 65 mg/kg or 3 grams daily, whichever is less. When the blood pressure is under control, continue with oral therapy using tablets in the same dosage as for the parenteral route.
  • Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Methyldopate in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Methyldopate in pediatric patients.

Contraindications

  • Methyldopate hydrochloride is contraindicated in patients:

Warnings

  • It is important to recognize that a positive Coombs test, hemolytic anemia, and liver disorders may occur with methyldopa therapy. The rare occurrences of hemolytic anemia or liver disorders could lead to potentially fatal complications unless properly recognized and managed. Read this section carefully to understand these reactions.
  • With prolonged methyldopa therapy, 10 to 20 percent of patients develop a positive direct Coombs test which usually occurs between 6 and 12 months of methyldopa therapy. Lowest incidence is at daily dosage of 1 gram or less. This on rare occasions may be associated with hemolytic anemia, which could lead to potentially fatal complications. One cannot predict which patients with a positive direct Coombs test may develop hemolytic anemia.

PRECAUTIONS

General
  • Methyldopa should be used with caution in patients with a history of previous liver disease or dysfunction.
  • Rarely involuntary choreoathetotic movements have been observed during therapy with methyldopa in patients with severe bilateral cerebrovascular disease. Should these movements occur, stop therapy.

Adverse Reactions

Clinical Trials Experience

  • Sedation, usually transient, may occur during the initial period of therapy or whenever the dose is increased. Headache, asthenia, or weakness may be noted as early and transient symptoms. However, significant adverse effects due to methyldopa have been infrequent and this agent usually is well tolerated.
  • The following adverse reactions have been reported and, within each category, are listed in order of decreasing severity.
Cardiovascular:
  • Aggravation of angina pectoris, congestive heart failure, prolonged carotid sinus hypersensitivity, paradoxical pressor response with intravenous use, orthostatic hypotension (decrease daily dosage), edema and weight gain, bradycardia.
Digestive:
  • Pancreatitis, colitis, vomiting, diarrhea, sialadenitis, sore or ``black′′ tongue, nausea, constipation, distension, flatus, dryness of mouth.
Endocrine:
  • Hyperprolactinemia.
Hematologic:
  • Bone marrow depression, leukopenia, granulocytopenia, thrombocytopenia, hemolytic anemia; positive tests for antinuclear antibody, LE cells, and rheumatoid factor, positive Coombs tests.
Hepatic:
  • Liver disorders including hepatitis, jaundice, abnormal liver function test
Hypersensitivity:
  • Myocarditis, pericarditis, vasculitis, lupus-like syndrome, drug-related fever, eosinophilia.
Nervous System/Psychiatric:
  • Parkinsonism, Bell's palsy, decreased mental acuity, choreoathetotic movements, symptoms of cerebrovascular insufficiency, psychic disturbances including nightmares and reversible mild psychoses or depression, headache, sedation, asthenia or weakness, dizziness, lightheadedness, paresthesias.
Metabolic:
  • Rise in BUN
Musculoskeletal:
  • Arthralgia, with or without joint swelling; myalgia.
Respiratory:
  • Nasal stuffiness.
Skin:
  • Toxic epidermal necrolysis, rash.
Urogenital:
  • Amenorrhea, breast enlargement, gynecomastia, lactation, impotence, decreased libido.

Postmarketing Experience

There is limited information regarding Methyldopate Postmarketing Experience in the drug label.

Drug Interactions

Laboratory Tests

  • Blood count, Coombs test, and liver function tests are recommended before initiating therapy and at periodic intervals.

Drug Interactions

  • When methyldopa is used with other antihypertensive drugs, potentiation of antihypertensive effect may occur. Patients should be followed carefully to detect side reactions or unusual manifestations of drug idiosyncrasy.
  • Patients may require reduced doses of anesthetics when on methyldopa. If hypotension does occur during anesthesia, it usually can be controlled by vasopressors. The adrenergic receptors remain sensitive during treatment with methyldopa.
  • When methyldopa and lithium are given concomitantly the patient should be carefully monitored for symptoms of lithium toxicity. Read the circular for lithium preparations.
  • Monoamine oxidase (MAO) inhibitors

Drug/Laboratory Test Interactions

  • Methyldopa may interfere with measurement of: urinary uric acid by the phosphotungstate method, serum creatinine by the alkaline picrate method, and SGOT by colorimetric methods. Interference with spectrophotometric methods for SGOT analysis has not been reported.
  • Since methyldopa causes fluorescence in urine samples at the same wavelengths as catecholamines, falsely high levels of urinary catecholamines may be reported. This will interfere with the diagnosis of pheochromocytoma. It is important to recognize this phenomenon before a patient with a possible pheochromocytoma is subjected to surgery. Methyldopa does not interfere with measurement of VMA (vanillylmandelic acid), a test for pheochromocytoma, by those methods which convert VMA to vanillin. Methyldopa is not recommended for the treatment of patients with pheochromocytoma. Rarely, when urine is exposed to air after voiding, it may darken because of breakdown of methyldopa or its metabolites.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): C

  • Animal reproduction studies have not been conducted with Methyldopate HCl. It is also not known whether Methyldopate HCl can affect reproduction capacity or can cause fetal harm when given to a pregnant woman. Methyldopate HCl should be given to a pregnant woman only if clearly needed.


Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Methyldopate in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Methyldopate during labor and delivery.

Nursing Mothers

  • Methyldopa appears in breast milk. Therefore, caution should be exercised when methyldopa is given to a nursing woman.

Pediatric Use

  • There are no well-controlled clinical trials in pediatric patients. Information on dosing in pediatric patients is supported by evidence from published literature regarding the treatment of hypertension in pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Methyldopate in geriatric settings.

Gender

There is no FDA guidance on the use of Methyldopate with respect to specific gender populations.

Race

There is no FDA guidance on the use of Methyldopate with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Methyldopate in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Methyldopate in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Methyldopate in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Methyldopate in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Injection, solution

Monitoring

There is limited information regarding Methyldopate Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Methyldopate and IV administrations.

Overdosage

  • Acute overdosage may produce acute hypotension with other responses attributable to brain and gastrointestinal malfunction (excessive sedation, weakness, bradycardia, dizziness, lightheadedness, constipation, distention, flatus, diarrhea, nausea, vomiting).
  • In the event of overdosage, symptomatic and supportive measures should be employed. Management includes special attention to cardiac rate and output, blood volume, electrolyte balance, paralytic ileus, urinary function and cerebral activity.
  • Sympathomimetic drugs [e.g., levarterenol, epinephrine, ARAMINE* (Metaraminol Bitartrate, MSD)] may be indicated.
  • The acute intravenous LD50 of Methyldopate HCl in the mouse is 321 mg/kg.

Pharmacology

There is limited information regarding Methyldopate Pharmacology in the drug label.

Mechanism of Action

  • Methyldopate, an antihypertensive agent, is an aromatic-amino-acid decarboxylase inhibitor in animals and in man. Although the mechanism of action has yet to be conclusively demonstrated, the antihypertensive effect of methyldopa probably is due to its metabolism to alpha-methyl-norepinephrine, which then lowers arterial pressure by stimulation of central inhibitory alpha-adrenergic receptors, false neurotransmission, and/or reduction of plasma renin activity. Methyldopa has been shown to cause a net reduction in the tissue concentration of serotonin, dopamine, norepinephrine, and epinephrine.
  • Only methyldopa, the L-isomer of alpha-methyldopa, has the ability to inhibit dopa decarboxylase and to deplete animal tissues of norepinephrine. In man, the antihypertensive activity appears to be due solely to the L-isomer. About twice the dose of the racemate (DL-alpha-methyldopa) is required for equal antihypertensive effect.
  • Methyldopa has no direct effect on cardiac function and usually does not reduce glomerular filtration rate, renal blood flow, or filtration fraction. Cardiac output usually is maintained without cardiac acceleration. In some patients the heart rate is slowed.
  • Normal or elevated plasma renin activity may decrease in the course of methyldopa therapy.
  • Methyldopa reduces both supine and standing blood pressure. It usually produces highly effective lowering of the supine pressure with infrequent symptomatic postural hypotension. Exercise hypotension and diurnal blood pressure variations rarely occur.

Structure

  • Methyldopate HCl Injection, USP, is an antihypertensive agent for intravenous use. Sterile, nonpyrogenic.
  • Methyldopate hydrochloride [levo-3-(3,4-dihydroxyphenyl)-2-methylalanine, ethyl ester hydrochloride] is the ethyl ester of methyldopa, supplied as the hydrochloride salt with a molecular weight of 275.73. Methyldopate hydrochloride is more soluble and stable in solution than methyldopa and is the preferred form for intravenous use.
  • The molecular formula for Methyldopate hydrochloride is C12H17NO4·HCl and the structural formula is:
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Methyldopate Pharmacodynamics in the drug label.

Pharmacokinetics

  • Methyldopate hydrochloride is the ethyl ester of methyldopa hydrochloride and possesses the same pharmacologic attributes.
  • Methyldopa is extensively metabolized. The known urinary metabolites are ∝-methyldopa mono-0-sulfate; 3-0-methyl-∝-methyldopa; 3,4-dihydroxyphenylacetone; ∝-methyldopamine; 3-0-methyl-∝-methyldopamine and their conjugates.
  • Following intravenous administration of methyldopate hydrochloride a decrease in blood pressure may occur in four to six hours and last 10 to 16 hours.
  • Approximately 49 percent of the dose of methyldopate hydrochloride is excreted in the urine as methyldopa and its mono-0-sulfate. The renal clearance of methyldopa following methyldopate hydrochloride is about 156 mL/min in normal subjects and is diminished in renal insufficiency. Following methyldopate hydrochloride injection the plasma half-life of methyldopa is 90-127 minutes. Approximately 17 percent of a dose of methyldopate hydrochloride given to normal subjects appears in plasma as free methyldopa.
  • Methyldopa crosses the placental barrier, appears in cord blood, and appears in breast milk.

Nonclinical Toxicology

Carcinogenesis, Mutagenesis, Impairment of Fertility

  • No evidence of a tumorigenic effect was seen when methyldopa was given for two years to mice at doses up to 1800 mg/kg/day or to rats at doses up to 240 mg/kg/day (30 and 4 times the maximum recommended human dose in mice and rats, respectively, when compared on the basis of body weight; 2.5 and 0.6 times the maximum recommended human dose in mice and rats, respectively, when compared on the basis of body surface area; calculations assume a patient weight of 50 kg).
  • Methyldopa was not mutagenic in the Ames Test and did not increase chromosomal aberration or sister chromatic exchanges in Chinese hamster ovary cells. These in vitro studies were carried out both with and without exogenous metabolic activation.
  • Fertility was unaffected when methyldopa was given to male and female rats at 100 mg/kg/day (1.7 times the maximum daily human dose when compared on the basis of body weight; 0.2 times the maximum daily human dose when compared on the basis of body surface area). Methyldopa decreased sperm count, sperm motility, the number of late spermatids and the male fertility index when given to male rats at 200 and 400 mg/kg/day (3.3 and 6.7 times the maximum daily human dose when compared on the basis of body weight; 0.5 and 1 times the maximum daily human dose when compared on the basis of body surface area).
  • Long-term studies in animals have not been performed to evaluate the carcinogenic potential of methyldopate hydrochloride; nor have evaluations of this ester's mutagenic potential or potential to affect fertility been carried out.

Clinical Studies

There is limited information regarding Methyldopate Clinical Studies in the drug label.

How Supplied

Methyldopate HCl Injection, USP 250 mg/5 mL (50 mg/mL).

NDC 0517-8905-10 5 mL Single Dose Vial Boxes of 10

Rx Only

IN8905 Rev. 11/05 MG #7604

AMERICAN REGENT, INC. SHIRLEY, NY 11967

Storage

Store at 20°-25°C (68°-77°F); excursions permitted to 15°-30°C (59°-86°F)

Images

Drug Images

{{#ask: Page Name::Methyldopate |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

PACKAGE LABEL.PRINCIPAL DISPLAY PANEL - CONTAINER

NDC 0517-8905-10

METHYLDOPATE HCl INJECTION, USP

250 mg/5 mL (50 mg/mL)

5 mL SINGLE DOSE VIAL

FOR IV USE AFTER DILUTION

Rx Only

AMERICAN REGENT, INC. SHIRLEY, NY 11967

This image is provided by the National Library of Medicine.

PRINCIPAL DISPLAY PANEL – Carton

METHYLDOPATE HCl INJECTION, USP

250 mg/5 mL (50 mg/mL)

NDC 0517-8905-10

10 x 5 mL SINGLE DOSE VIALS

FOR INTRAVENOUS USE AFTER DILUTION

Rx Only

Each mL contains: Methyldopate HCl 50 mg, Citric Acid (Anhydrous) 5 mg, Edetate Disodium 0.5 mg, Monothioglycerol 2 mg, Water for Injection q.s. Methylparaben 1.5 mg and Propylparaben 0.2 mg added as preservatives, Sodium Bisulfite 3.2 mg added as an antioxidant. pH adjusted with Sodium Hydroxide and/or Hydrochloric Acid. DISCARD UNUSED PORTION. Store at 20°-25°C (68°-77°F); excursions permitted to 15°-30°C (59°-86°F) (See USP Controlled Room Temperature). Directions for Use: See Package Insert.

AMERICAN REGENT, INC. SHIRLEY, NY 11967

Rev. 11/05

This image is provided by the National Library of Medicine.

{{#ask: Label Page::Methyldopate |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Methyldopate Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Methyldopate interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Methyldopate Brand Names in the drug label.

Look-Alike Drug Names

There is limited information regarding Methyldopate Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.