Palonosetron

	WikiDoc Resources for Palonosetron
Articles
Most recent articles on Palonosetron Most cited articles on Palonosetron Review articles on Palonosetron Articles on Palonosetron in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Palonosetron Images of Palonosetron Photos of Palonosetron Podcasts & MP3s on Palonosetron Videos on Palonosetron
Evidence Based Medicine
Cochrane Collaboration on Palonosetron Bandolier on Palonosetron TRIP on Palonosetron
Clinical Trials
Ongoing Trials on Palonosetron at Clinical Trials.gov Trial results on Palonosetron Clinical Trials on Palonosetron at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Palonosetron NICE Guidance on Palonosetron NHS PRODIGY Guidance FDA on Palonosetron CDC on Palonosetron
Books
Books on Palonosetron
News
Palonosetron in the news Be alerted to news on Palonosetron News trends on Palonosetron
Commentary
Blogs on Palonosetron
Definitions
Definitions of Palonosetron
Patient Resources / Community
Patient resources on Palonosetron Discussion groups on Palonosetron Patient Handouts on Palonosetron Directions to Hospitals Treating Palonosetron Risk calculators and risk factors for Palonosetron
Healthcare Provider Resources
Symptoms of Palonosetron Causes & Risk Factors for Palonosetron Diagnostic studies for Palonosetron Treatment of Palonosetron
Continuing Medical Education (CME)
CME Programs on Palonosetron
International
Palonosetron en Espanol Palonosetron en Francais
Business
Palonosetron in the Marketplace Patents on Palonosetron
Experimental / Informatics
List of terms related to Palonosetron

Palonosetron
Clinical data
AHFS/Drugs.com	Monograph
MedlinePlus	a610002
[[Regulation of therapeutic goods \|Template:Engvar data]]	US FDA: Palonosetron;
Pregnancy; category	AU: B1 ; US: B (No risk in non-human studies) ; ;
Routes of; administration	Intravenous, oral
ATC code	A04AA05 (WHO) ;
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Bioavailability	97% (oral)
Protein binding	62%
Metabolism	Hepatic, 50% (mostly CYP2D6-mediated, CYP3A4 and CYP1A2 also involved)
Elimination half-life	Approximately 40 hours
Excretion	Renal, 80% (of which 49% unchanged); fecal (5 to 8%)
Identifiers
	IUPAC name (3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one;
CAS Number	135729-61-2 ;
PubChem CID	148211;
DrugBank	DB00377 ;
ChemSpider	4892289 ;
UNII	5D06587D6R;
ChEBI	CHEBI:85161 ;
ChEMBL	ChEMBL1189679 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C19H24N2O
Molar mass	296.407 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C5N([C@H]2C1CCN(CC1)C2)C[C@@H]4c3c5cccc3CCC4;
	InChI InChI=1S/C19H24N2O/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20/h2,4,6,13,15,17H,1,3,5,7-12H2/t15-,17-/m1/s1 ; Key:CPZBLNMUGSZIPR-NVXWUHKLSA-N ;
(what is this?) (verify)

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Palonosetron (INN, trade name Aloxi) is a 5-HT₃ antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is used for the control of delayed CINV—nausea and vomiting and there are tentative data to suggest that it may be better than granisetron.^[1]

Palonosetron is administered intravenously, as a single dose, 30 minutes before chemotherapy,^[2] or as a single oral capsule one hour before chemotherapy.^[3] The oral formulation was approved on August 22, 2008 for prevention of acute CINV alone, as a large clinical trial did not show oral administration to be as effective as intravenous use against delayed CINV.^[3]

References

↑ Billio, A; Morello, E; Clarke, MJ (Jan 20, 2010). "Serotonin receptor antagonists for highly emetogenic chemotherapy in adults". The Cochrane database of systematic reviews (1): CD006272. doi:10.1002/14651858.CD006272.pub2. PMID 20091591.
↑ De Leon A (2006). "Palonosetron (Aloxi): a second-generation 5-HT(3) receptor antagonist for chemotherapy-induced nausea and vomiting". Proceedings (Baylor University. Medical Center). 19 (4): 413–6. PMC 1618755. PMID 17106506.
↑ ^3.0 ^3.1 Waknine, Yael (September 4, 2008). "FDA Approvals: Nplate, Aloxi, Vidaza". Medscape. Retrieved 2008-09-04. Freely available with registration.

Template:5-HT3 antagonists

Template:Gastrointestinal-drug-stub

[1] Billio, A; Morello, E; Clarke, MJ (Jan 20, 2010). "Serotonin receptor antagonists for highly emetogenic chemotherapy in adults". The Cochrane database of systematic reviews (1): CD006272. doi:10.1002/14651858.CD006272.pub2. PMID 20091591.

[pmid17106506-2] De Leon A (2006). "Palonosetron (Aloxi): a second-generation 5-HT(3) receptor antagonist for chemotherapy-induced nausea and vomiting". Proceedings (Baylor University. Medical Center). 19 (4): 413–6. PMC 1618755. PMID 17106506.

[Medscape-3] 3.0 ^3.1 Waknine, Yael (September 4, 2008). "FDA Approvals: Nplate, Aloxi, Vidaza". Medscape. Retrieved 2008-09-04. Freely available with registration.

[1]

[2]

[3]

Palonosetron

Overview

See also

References

Navigation menu