Diiodotyrosine

Diiodotyrosine
Identifiers
CAS Number	66-02-4 ;
3D model (JSmol)	Interactive image;
ChemSpider	8946 ;
ECHA InfoCard	Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
MeSH	Diiodotyrosine
PubChem CID	6181; 7058163;
UNII	6L57Q44ZWW ;
	InChI InChI=1S/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1 Key: NYPYHUZRZVSYKL-ZETCQYMHSA-N ; InChI=1/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1 Key: NYPYHUZRZVSYKL-ZETCQYMHBZ;
	SMILES Ic1cc(cc(I)c1O)C[C@@H](C(=O)O)N;
Properties
Chemical formula	C9H9I2NO3
Molar mass	432.982 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Template:Chembox E number

Diiodotyrosine (DIT) is a precursor in the production of thyroid hormone, and results from iodization of monoiodotyrosine at the other meta- position on the phenol ring.

Function

DIT is a modulator of the enzyme thyroid peroxidase (which is involved in the production of thyroid hormones).^[1]

Triiodothyronine is formed, when diiodotyrosine is combined with monoiodotyrosine (in the colloid of the thyroid follicle).

Two molecules of DIT combine to make the thyroid hormone thyroxine ('T4' and 'T3').

References

↑ Dème D, Fimiani E, Pommier J, Nunez J (February 1975). "Free diiodotyrosine effects on protein iodination and thyroid hormone synthesis catalyzed by thyroid peroxidase". Eur. J. Biochem. 51 (2): 329–36. doi:10.1111/j.1432-1033.1975.tb03932.x. PMID 1149735.

External links

H03BX01 (WHO)

Template:Thyroid therapy Template:Thyroid hormone intermediates

Template:Organohalide-stub

[pmid1149735-1] Dème D, Fimiani E, Pommier J, Nunez J (February 1975). "Free diiodotyrosine effects on protein iodination and thyroid hormone synthesis catalyzed by thyroid peroxidase". Eur. J. Biochem. 51 (2): 329–36. doi:10.1111/j.1432-1033.1975.tb03932.x. PMID 1149735.

[1]

Diiodotyrosine

Contents

Function

See also

References

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Identifiers

CAS Number	66-02-4^Y
3D model (JSmol)	Interactive image
ChemSpider	8946^N
ECHA InfoCard	Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
MeSH	Diiodotyrosine
PubChem CID	6181 7058163
UNII	6L57Q44ZWW^Y
InChI InChI=1S/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1^N Key: NYPYHUZRZVSYKL-ZETCQYMHSA-N^N InChI=1/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1 Key: NYPYHUZRZVSYKL-ZETCQYMHBZ
SMILES Ic1cc(cc(I)c1O)C[C@@H](C(=O)O)N
Properties
Chemical formula	C₉H₉I₂NO₃
Molar mass	432.982 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is ^YN ?)
Infobox references