Thiram

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Thiram

Names
IUPAC name dimethylcarbamothioylsulfanyl N,N-dimethylcarbamodithioate
Identifiers
CAS Number	137-26-8 N
3D model (JSmol)	Interactive image
ECHA InfoCard
KEGG	D06114 Y
PubChem CID	5455
SMILES CN(C)C(=S)SSC(=S)N(C)C
Properties
Chemical formula	C6H12N2S4
Molar mass	240.43288
Hazards
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Synonyms and keywords: Tetramethylthiuram disulfide

Overview

Thiram is an ectoparasiticide. It is used to prevent fungal diseases in seed and crops. It is also used as an animal repellent to protect fruit trees and ornamentals from damage by rabbits, rodents and deer. It is effective against Stem gall of coriander, damping off, smut of millet, neck rot of onion, etc. Thiram has been used in the treatment of human scabies, as a sun screen and as a bactericide applied directly to the skin or incorporated into soap.

Chemical properties

Thiram is a type of sulfur fungicide. It has been found to dissolve completely in chloroform, acetone and ether. It is available as dust, flowable, wettable powder, water dispersible granules, and water suspension formulations and in mixtures with other fungicides.

Thiram is nearly immobile in clay soils or in soils of high organic matter. It is not expected to contaminate groundwater because of its in-soil half life of 15 days and tendency to stick to soil particles.

Acute Toxicity

Thiram is moderately toxic by ingestion, but it is highly toxic if inhaled. Acute exposure in humans may cause headaches, dizziness, fatigue, nausea, diarrhea and other gastrointestinal complaints.

Thiram is irritating to the eyes, skin and respiratory tract. It is a skin sensitizer. Symptoms of acute inhalation exposure to thiram include itching, scratchy throat, hoarseness, sneezing, coughing, inflammation of the nose or throat, bronchitis, dizziness, headaches, fatigue, nausea, diarrhea and other gastro-intestinal complaints. Persons with chronic respiratory or skin disease are at increased risk from exposure to thiram.

Chronic Toxicity

In addition to the symptoms of acute exposure, symptoms of chronic exposure to thiram in humans include drowsiness, confusion, loss of sex drive, incoordination, slurred speech and weakness. Repeated or prolonged exposure to thiram can also cause allergic reactions such as dermatitis, watery eyes, sensitivity to light and conjunctivitis.