Flutemetamol (18F)

Flutemetamol (¹⁸F)

Clinical data
Trade names	Vizamyl
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Intravenous
ATC code	V09AX04 (WHO)
Legal status
Legal status	US: ℞-only
Identifiers
IUPAC name 2-[3-(18F)Fluoro-4-(methylamino)phenyl]-1,3-benzothiazol-6-ol
PubChem CID	15950376
ChemSpider	13092196
UNII	0F3M7032P5
ChEBI	CHEBI:76611
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C14H1118FN2OS
Molar mass	273.316 g/mol
3D model (JSmol)	Interactive image
SMILES CNC1=C(C=C(C=C1)C2=NC3=C(S2)C=C(C=C3)O)[18F]
InChI InChI=1S/C14H11FN2OS/c1-16-11-4-2-8(6-10(11)15)14-17-12-5-3-9(18)7-13(12)19-14/h2-7,16,18H,1H3/i15-1 Key:VVECGOCJFKTUAX-HUYCHCPVSA-N

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Flutemetamol (¹⁸F) (trade name Vizamyl, by GE Healthcare) is a PET scanning radiopharmaceutical containing the radionuclide fluorine-18, used as a diagnostic tool for Alzheimer's disease.

Mechanism of action

After the substance is given intravenously, it accumulates in beta amyloid plaques in the patient's brain, which thus become visible via positron emission tomography (PET).