Masoprocol

Masoprocol

Clinical data
Trade names	Actinex
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	US: B (No risk in non-human studies)
Routes of administration	Topical
ATC code	L01XX10 (WHO)
Pharmacokinetic data
Bioavailability	Very low
Identifiers
IUPAC name 4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
CAS Number	500-38-9 Y
PubChem CID	71398
IUPHAR/BPS	4265
DrugBank	DB00179 Y
ChemSpider	64490 Y
UNII	7BO8G1BYQU
ChEBI	CHEBI:73468 N
ChEMBL	ChEMBL313972 N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C18H22O4
Molar mass	302.365 g/mol
3D model (JSmol)	Interactive image
SMILES Oc1ccc(cc1O)C[C@H](C)[C@H](C)Cc2ccc(O)c(O)c2
InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+ Y Key:HCZKYJDFEPMADG-TXEJJXNPSA-N Y
NY (what is this?)  (verify)

WikiDoc Resources for Masoprocol
Articles
Most recent articles on Masoprocol Most cited articles on Masoprocol Review articles on Masoprocol Articles on Masoprocol in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Masoprocol Images of Masoprocol Photos of Masoprocol Podcasts & MP3s on Masoprocol Videos on Masoprocol
Evidence Based Medicine
Cochrane Collaboration on Masoprocol Bandolier on Masoprocol TRIP on Masoprocol
Clinical Trials
Ongoing Trials on Masoprocol at Clinical Trials.gov Trial results on Masoprocol Clinical Trials on Masoprocol at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Masoprocol NICE Guidance on Masoprocol NHS PRODIGY Guidance FDA on Masoprocol CDC on Masoprocol
Books
Books on Masoprocol
News
Masoprocol in the news Be alerted to news on Masoprocol News trends on Masoprocol
Commentary
Blogs on Masoprocol
Definitions
Definitions of Masoprocol
Patient Resources / Community
Patient resources on Masoprocol Discussion groups on Masoprocol Patient Handouts on Masoprocol Directions to Hospitals Treating Masoprocol Risk calculators and risk factors for Masoprocol
Healthcare Provider Resources
Symptoms of Masoprocol Causes & Risk Factors for Masoprocol Diagnostic studies for Masoprocol Treatment of Masoprocol
Continuing Medical Education (CME)
CME Programs on Masoprocol
International
Masoprocol en Espanol Masoprocol en Francais
Business
Masoprocol in the Marketplace Patents on Masoprocol
Experimental / Informatics
List of terms related to Masoprocol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. A form of nordihydroguaiaretic acid that is taken by mouth is being studied in the treatment of prostate cancer.

Also called nordihydroguaiaretic acid, NDGA, and actinex.

Mechanism

Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth.

It is a lipoxygenase inhibitor.

External links

• MedlinePlus Drug Information
• Actinex entry in the public domain NCI Cancer Dictionary