Strontium chloride

Strontium chloride
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rabin Bista, M.B.B.S. [2]

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Overview

Strontium chloride is a metal halide that is FDA approved for the treatment of bone pain in patients with painful skeletal metastases.. Common adverse reactions include increased pain, flushing, fatigue.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indications

STRONTIUM CHLORIDE Sr-89 INJECTION, USP is indicated for the relief of bone pain in patients with painful skeletal metastases.

The presence of bone metastases should be confirmed prior to therapy.

Dosage

The recommended dose of Strontium-89 Chloride is 148 MBq, 4 mCi, administered by slow intravenous injection (1-2 minutes). Alternatively, a dose of 1.5 - 2.2 MBq/kg, 40-60 µCi/kg body weight may be used.

Repeated administrations of Strontium-89 Chloride should be based on an individual patient’s response to therapy, current symptoms, and hematologic status, and are generally not recommended at intervals of less than 90 days.

The patient dose should be measured by a suitable radioactivity calibration system immediately prior to administration.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Strontium chloride in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Strontium chloride in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

• Safety and effectiveness in children below the age of 18 years have not been established.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Strontium chloride in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Strontium chloride in pediatric patients.

Contraindications

• None

Warnings

• Description

Precautions

• Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Strontium chloride in the drug label.

Body as a Whole

Cardiovascular

Digestive

Endocrine

Hematologic and Lymphatic

Metabolic and Nutritional

Musculoskeletal

Neurologic

Respiratory

Skin and Hypersensitivy Reactions

Special Senses

Urogenital

Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Strontium chloride in the drug label.

Body as a Whole

Cardiovascular

Digestive

Endocrine

Hematologic and Lymphatic

Metabolic and Nutritional

Musculoskeletal

Neurologic

Respiratory

Skin and Hypersensitivy Reactions

Special Senses

Urogenital

Miscellaneous

Drug Interactions

• Drug

• Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

• Pregnancy Category

Pregnancy Category (AUS):

• Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Strontium chloride in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Strontium chloride during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Strontium chloride with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Strontium chloride with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Strontium chloride with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Strontium chloride with respect to specific gender populations.

Race

There is no FDA guidance on the use of Strontium chloride with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Strontium chloride in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Strontium chloride in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Strontium chloride in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Strontium chloride in patients who are immunocompromised.

Administration and Monitoring

Administration

• Oral

• Intravenous

Monitoring

There is limited information regarding Monitoring of Strontium chloride in the drug label.

• Description

IV Compatibility

There is limited information regarding IV Compatibility of Strontium chloride in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

• Description

Management

• Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Strontium chloride in the drug label.

Pharmacology

There is limited information regarding Strontium chloride Pharmacology in the drug label.

Mechanism of Action

Structure

File:Strontium chloride01.png

This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Strontium chloride in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Strontium chloride in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Strontium chloride in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Strontium chloride in the drug label.

How Supplied

Storage

There is limited information regarding Strontium chloride Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Patient Counseling Information of Strontium chloride in the drug label.

Precautions with Alcohol

• Alcohol-Strontium chloride interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

• ®

Look-Alike Drug Names

• A® — B®

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

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