Bendroflumethiazide

Bendroflumethiazide

Clinical data
AHFS/Drugs.com	Consumer Drug Information
Pregnancy category	Risk neonatal thrombocytopenia in 3rd trimester
Routes of administration	Oral
ATC code	C03AA01 (WHO)
Legal status
Legal status	UK: POM (Prescription only)
Pharmacokinetic data
Bioavailability	100%
Protein binding	96%
Metabolism	extensive
Elimination half-life	3-4 hours
Identifiers
IUPAC name 3-Benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4- benzothiadiazine-7-sulfonamide
CAS Number	73-48-3 Y
PubChem CID	2315
DrugBank	DB00436 Y
ChemSpider	2225 Y
UNII	5Q52X6ICJI
KEGG	D00650 Y
ChEBI	CHEBI:3013 Y
ChEMBL	ChEMBL1684 Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C15H14F3N3O4S2
Molar mass	421.415 g/mol
3D model (JSmol)	Interactive image
SMILES FC(F)(F)c3c(cc1c(NC(NS1(=O)=O)Cc2ccccc2)c3)S(=O)(=O)N
InChI InChI=1S/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23) Y Key:HDWIHXWEUNVBIY-UHFFFAOYSA-N Y
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Clinical Trials
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Guidelines / Policies / Govt
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Definitions
Definitions of Bendroflumethiazide
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Experimental / Informatics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Bendroflumethiazide (INN), formerly bendrofluazide (BAN), trade name Aprinox, is a thiazide diuretic used to treat hypertension.

Bendroflumethiazide is a thiazide diuretic which works by inhibiting sodium reabsorption at the beginning of the distal convoluted tubule (DCT). Water is lost as a result of more sodium reaching the collecting ducts. Bendroflumethiazide has a role in the treatment of mild heart failure although loop diuretics are better for reducing overload. The main use of bendroflumethiazide currently is in hypertension (part of the effect is due to vasodilation).

Common adverse effects:

• postural hypotension
• hyponatraemia, hypokalaemia, hypercalcaemia
• gout
• impaired glucose tolerance
• impotence

Rare adverse effects:

• thrombocytopenia
• agranulocytosis
• pancreatitis